195531-22-7

Usage

Uses

Used in Pharmaceutical Research:
(4-aminophenyl)(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(3aH)-yl)methanone is used as a subject of research for its potential pharmacological properties. The presence of a ketone functional group and the unique heterocyclic structure of the compound suggests that it may have applications in the development of new drugs.
Used in Drug Development:
In the field of drug development, (4-aminophenyl)(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(3aH)-yl)methanone is considered for its potential to contribute to the creation of novel therapeutic agents. (4-aminophenyl)(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(3aH)-yl)methanone's structure and functional groups may offer new avenues for treating various medical conditions once its biological activity is thoroughly understood.

Upstream product

• 105895-93-0 methyl 2-{(3-cyanopropyl)[(4-methylphenyl)sulfonyl]amino}benzoate 
• 318237-73-9 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 
• 137975-89-4 1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 
• 168626-71-9 2-methyl-6-(4-nitrobenzoyl)-1,4,5,6-tetrahydroimidazo-[4,5-d][1]benzazepine 
• 169879-06-5 4-bromo-1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 
• 717917-14-1 2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 
• 24310-36-9 1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 
• 50998-74-8 methyl N-tosylanthranilate 
• 29489-04-1 4-bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 
• 134-20-3 2-carbomethoxyaniline 
• 122-04-3 4-nitro-benzoyl chloride 
• 68595-19-7 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carbonitrile 

Downstream Products

• 168626-94-6 conivaptan hydrochloride 

Relevant academic research and scientific papers

A new synthetic route to YM087, an arginine vasopressin antagonist

A new synthesis of N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl} biphenyl-2-carboxamide monohydrochloride (1, YM087) via new imidazobenzazepine intermediates is described. This method remarkably improves the overall yiel

Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1] benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: An Arginine Vasopressin Antagonist

A novel, reliable, and cost-effective synthetic route to N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl] -phenyl}biphenyl-2-carboxamide monohydrochloride (1, YM087), a potent Arginine vasopressin antagonist, has been developed. Using moisture-controlled potassium carbonate, imidazole formation from α-bromoketone furnished imidazobenzazepine, avoiding potential oxazole-ring formation. Catalytic reduction of nitro imidazobenzazepine afforded the corresponding amine in high yields. Treatment of the imidazole-containing amine directly, with a carbonyl chloride, afforded the target amide circumventing protection of the imidazole.