138026-97-8

Basic information

• Product Name: 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI)
• Synonyms: cis-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate;tert-Butyl(cis)-3-amino-4-hydroxypyrrolidine-1-carboxylate;cis-(3S,4R)-tert-Butyl 3-Amino-4-hydroxypyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI);tert-Butyl (3S,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate;cis-3-AMino-1-Boc-4-hydroxypyrrolidine;Cis-1-Boc-3-aMino-4-hydroxypyrrolidine;rel-tert-Butyl (3S,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate
• CAS NO: 138026-97-8
• Molecular Formula: C9H18N2O3
• Molecular Weight: 202.25
• Product Categories: AMINOACID
• Mol File: 138026-97-8.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 308.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.179±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.36±0.40(Predicted)
• CAS DataBase Reference: 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI)(138026-97-8)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI)(138026-97-8)

Safety Data

• Hazardous Substances Data: 138026-97-8(Hazardous Substances Data)

Usage

Description

1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI), also known as L-proline ethyl ester, is a chemical compound derived from the amino acid proline. It is commonly used in organic synthesis and has been studied for its potential biological and pharmaceutical applications. L-proline ethyl ester serves as a chiral building block in the production of pharmaceuticals and is considered a potential therapeutic agent for various medical conditions. Due to its potential health hazards, it is important to handle this chemical with care and use it in a controlled manner in laboratory settings.

Uses

Used in Pharmaceutical Industry:
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI) is used as a chiral building block for the production of pharmaceuticals. Its unique structure allows for the creation of enantiomerically pure compounds, which are essential in the development of effective and safe medications.
Used in Organic Synthesis:
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI) is used as a key intermediate in the synthesis of various organic compounds. Its versatile functional groups enable it to participate in a wide range of chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Research and Development:
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,cis-(9CI) is used as a research tool in the study of biological and pharmaceutical applications. Its potential as a therapeutic agent for various medical conditions makes it an important compound for further investigation and development in the scientific community.

Upstream product

• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 151259-38-0 tert-butyl diallylcarbamate 
• 1202067-37-5 (3R,4R)-3-hydroxy-4-(2,2,2-trifluoroacetylamino)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1202067-36-4 (3R,4R)-3-azido-4-(trimethylsilanyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 330681-18-0 (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1214272-52-2 (3R,4R)-tert-butyl 3-azido-4-hydroxypyrrolidine-1-carboxylate 
• 1214272-51-1 (3R,4R)-trans-N-Boc-3-acetoxy-4-azidopyrrolidine 
• 1374429-77-2 (3R,4S)-tert-butyl 3-azido-4-(bis(4-methoxyphenyl)(phenyl)methoxy)pyrrolidine-1-carboxylate 
• 926913-11-3 (3S,4S)-1-N-tert-butyloxycarbonyl-4-(4,4'-dimethoxytrityloxy)-3-mesyloxy-pyrrolidine 
• 1202067-38-6 (3aR,6aS)-2-trifluoromethyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d]oxazole-5-carboxylic acid fert-butyl ester 
• 926912-99-4 (3S,4R)-1-N-tert-butyloxycarbonyl-4-(4,4'-dimethoxytrityloxy)-3-mesyloxy-pyrrolidine 
• 203434-45-1 (±)-tert-butyl 3-azido-4-hydroxypyrrolidine-1-carboxylate 

Downstream Products

• 138026-97-8 (3R,4S)-4-amino-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine 
• 1333414-02-0 (3S,4S)-tert-butyl 3-(tert-butyldiphenylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine-1-carboxylate 
• 1202067-41-1 (3aS,6aR)-2-phenyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d]oxazole-5-carboxylic acid tert-butyl ester 
• 1214272-56-6 (3S,4S)-trans-N-Boc-3-acetylthio-4-(4-phenoxybenzenesulfonamido)pyrrolidine 
• 1214272-57-7 (3S,4S)-trans-N-Boc-3-mercapto-4-(4-phenoxybenzenesulfonamido)pyrrolidine 
• 1214272-55-5 (3R,4S)-cis-N-Boc-3-hydroxy-4-(4-phenoxybenzenesulfonamido)pyrrolidine 
• 1174020-29-1 cis-3-amino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1215485-03-2 3,4-diaminopyrrolidinyl-1-carboxylic acid tert-butyl ester 
• 1215210-04-0 (3S,4S)-3-amino-4-hydroxypyrrolidine dihydrochloride 
• 859213-33-5 (3S,4S)-tert-butyl 3-(dimethyl amino)-4-hydroxypyrrolidine-1-carboxylate 
• 138026-93-4 (trans)-tert-butyl hexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate 

Relevant articles and documents

Guanidine derivative and application thereof

The invention relates to a guanidine derivative serving as a VAP-1 inhibitor and application of the guanidine derivative, and further relates to a pharmaceutical composition containing the compound. The compound or the pharmaceutical composition can be us

NOVEL HETEROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS

The present invention relates to novel compounds of the general formula (I) their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically accepted salts, or pro-drugs thereof, which are useful for the treatment or prevention of cancer and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), and more particularly compounds that modulate the function of IRAK4.

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

Compounds of formula (I') and methods of their use and preparation, as well as compositions comprising compounds of formula (I').