13808-73-6Relevant academic research and scientific papers
Base-mediated N- And O-arylations of NH-containing heterocycles, heterocyclic amines and phenols
Ghasemi, Zarrin,Shahrak, Nasim Shahi,Roomi, Behzad Jalali,Zakeri, Ziba
, p. 73 - 75 (2015)
Nucleophilic substitution reactions of N-heterocycles such as imidazole, benzimidazole, indole and pyrazole as well as NH2 or OH containing heterocycles, with electron-deficient aryl halides in the presence of t-BuOK or K2CO3as base and DMSO as solvent are reported. A series of N-aryl azoles, unsymmetric diaryl ethers and diaryl amines were obtained in good yields.
NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF
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Paragraph 0136, (2021/11/04)
The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.
Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof
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Paragraph 0639; 0641-0643, (2020/08/28)
The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.
Water-soluble cyclic palladium hydrate mono-phosphine salt compound, and preparation method and application thereof
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Paragraph 0029, (2017/08/29)
The invention relates to a water-soluble cyclic palladium hydrate mono-phosphine salt compound, and a preparation method and an application thereof. The compound has a formula shown in the specification, wherein L is a sulfo group-containing mono-phosphine ligand, a phosphine atom and a palladium coordinate; the hydroxy benzyl groups can be singly or simultaneously located on a pyridine ring and a benzene ring; and the hydroxy benzyl groups can be located on any positions on the two rings. According to the invention, the cyclic palladium dimer containing the hydroxy benzyl groups and the sodium salt of the sulfo group-containing mono-phosphine ligand react with each other in an acetone solvent, so that the corresponding water-soluble cyclic palladium hydrate mono-phosphine salt compound can be conveniently synthesized. When the compound is used as a metal catalyst, the dosage of the catalyst is small; clean water used as the solvent and low-cost weak base can be utilized to effectively catalyze the coupled reaction between aryl halide and pyrazole, so as to synthesize and prepare 1-aryl pyrazole. The method has the advantages that the scope of the reaction substrate is wide, the reaction condition is mild, the yield is high, the method is economical and efficient and the method has an important application value.
