1382469-18-2Relevant academic research and scientific papers
Expedient synthesis of SMAMPs via click chemistry
Fu, Tsung-Hao,Li, Yan,Thaker, Hitesh D.,Scott, Richard W.,Tew, Gregory N.
, p. 841 - 845 (2013)
A novel series of synthetic mimics of antimicrobial peptides (SMAMPs) containing triazole linkers were assembled using click chemistry. While only moderately active in buffer alone, an increase in antimicrobial activity against Staphylococcus aureus and Escherichia coli was observed when these SMAMPs were administered in the presence of mouse serum. One compound had minimum inhibitory concentrations (MICs) of 0.39 μg/mL and 6.25 μg/mL, respectively, and an HC50 of 693 μg/mL. These values compared favorably to peptide-based antimicrobials. A correlation between the net positive charge and SMAMP antimicrobial activity was observed. The triazole linker, an amide surrogate, was found to provide better antimicrobial activity against both S. aureus and E. coli when compared to other analogues.
CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
-
, (2013/07/05)
The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
Synthetic mimics of antimicrobial peptides with immunomodulatory responses
Thaker, Hitesh D.,Som, Abhigyan,Ayaz, Furkan,Lui, Dahui,Pan, Wenxi,Scott, Richard W.,Anguita, Juan,Tew, Gregory N.
supporting information; experimental part, p. 11088 - 11091 (2012/08/28)
A new series of aryl-based synthetic mimics of antimicrobial peptides (SMAMPs) with antimicrobial activity and selectivity have been developed via systematic tuning of the aromatic groups and charge. The addition of a pendant aromatic group improved the a
