138432-74-3

Upstream product

• 1613-94-1 (E)-N-benzylidene-4-nitroaniline 
• 536-74-3 phenylacetylene 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 100-42-5 styrene 
• 100-52-7 benzaldehyde 
• 100-01-6 4-nitro-aniline 
• 100-25-4 para-dinitrobenzene 
• 14309-92-3 N-benzyl-4-nitroaniline 
• 4663-33-6 1,3-diphenyl-3-hydroxypropene 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 98-86-2 acetophenone 

Downstream Products

• 1252556-10-7 N,N-bis(4-aminophenyl)-2,4-diphenylquinolin-6-amine 
• 1252556-09-4 N,N-bis(4-nitrophenyl)-2,4-diphenylquinolin-6-amine 

Relevant academic research and scientific papers

Environmental effects in nitroquinoline derivatives solutions: Solvatochromism, acid-base effect and ion-sensor investigation

Since the first chemical fluorescent sensor reported in 1867, it has often been sought to find intelligent organic molecules that act as chemical sensors of high selectivity and sensitivity. In this process, the colorimetric and fluorescence methods have more advantages, as they are generally very sensitive, low cost, easily executable, versatile and of quick result. Colorimetric receptors containing several chromophores with azo-compounds have been developed since the discovery of chemosensors. Quinoline derivatives attract the interest of the scientific community in this regard. Thus, the present study using a facile synthesis aimed to help in development and behavioural study of new nitroquinolinic compounds against different solvents, pHs and organic/inorganic salts to observe potential recognition of anionic or cationic species. In four compounds a good non-linear fitting between the absorption intensity and amount of acid/base were established. The structural characterization of each of the prepared compounds was carried out with different spectroscopic and spectrometric techniques. UV–Vis and fluorescence measurements were also essential to confirm the binding/interaction process of ionic species and helped to find molecules with potential use in the identification of Co2+ and U2+ species, in addition to showing the sensitivity of species to pH and different solvents. The combination of theory and experiment is able to give a better understanding of the behavior in acidic, basic and neutral medium, DFT calculations were employed for this purpose.

Green synthesis of quinolines via A3-coupling by using graphene oxide-supported Br?nsted acidic ionic liquid

Abstract: Graphene oxide-supported Bronsted acidic ionic liquid ([GrBenzImi]SO3H) has been prepared by covalent grafting of benzimidazole unit in the matrix of graphene oxide followed by reaction with 1,4-butane sultone and hydrochloric acid. [GrBenzImi]SO3H has been characterized by various techniques including Fourier transform infrared spectroscopy (FTIR), FT-Raman (FT-Raman spectroscopy), CP-MAS 13C NMR spectroscopy, thermogravimetric analysis, energy-dispersive X-ray analysis, Brunauer–Emmett–Teller surface area, X-ray diffraction, and transmission electron microscopy. [GrBenzImi]SO3H was successfully employed as heterogeneous catalyst in A3-coupling reaction of aryl aldehydes, anilines and phenylacetylene for the synthesis of 2,4-disubstituted quinolines using water/ethanol system (1:1) as green medium. [GrBenzImi]SO3H could be recycled six times without significant loss in the yield of product. Graphic abstract: [Figure not available: see fulltext.].

Synthesis method of 2, 4-diarylquinoline compound

The invention relates to a synthesis method of a 2, 4-diarylquinoline compound (II), which comprises the following steps: mixing a compound represented by a formula (I), an oxidizing agent and an organic solvent, heating to 60-80 DEG C, reacting for 1-2 hours, and carrying out after-treatment on the reaction solution to obtain a product (II). According to the synthesis method, a metal and other additives are not needed, operation is easy, raw materials are easy to obtain, and conditions are mild.

Synthesis of 2,4-Diarylquinoline Derivatives via Chloranil-Promoted Oxidative Annulation and One-Pot Reaction

An oxidative annulation for the synthesis of 2,4-diarylquinolines from o -allylanilines is disclosed that uses recyclable reagent Chloranil as the oxidant. The corresponding products are obtained in moderate to excellent yields. Furthermore, a one-pot access to 2,4-di aryl quinolines from easily available anilines and 1,3-diarylpropenes is described as a highly atom-efficient protocol that involves oxidative coupling, rearrangement, and oxidative annulation.

NbCl5 a multifunctional reagent for the synthesis of new halogenated aminoquinoline compounds through innovative one-pot reaction and the acidochromism effect

This paper describes an original one-pot way to synthesize nine new halogenated aminoquinoline derivatives using reactions conducted by niobium pentachloride. Subsequently, we describe an efficient and selective reduction reaction of nitroquinolines using niobium pentachloride and zinc, producing important compounds in the organic synthesis. The results showed that it is an important tool to synthesize these compounds, besides being time- and resources-saving and generating good yields. A quick study of acidochromism was performed.

Synthesis of Quinolines and Pyrido[3,2- g or 2,3- g]quinolines Catalyzed by Heterogeneous Propylphosphonium Tetrachloroindate Ionic Liquid

This report explains an efficient method for synthesis of an array of quinolines via the reaction of 2-aminoaryl ketones with terminal and internal alkynes in the presence of propylphosphonium tetrachloroindate ionic liquid supported on nanosilica (PPInCl

Facile Synthesis and Photophysical Characterization of New Quinoline Dyes

This paper describes the synthesis of new quinoline derivatives, molecules that has been long interest in the organic and medicinal chemistry. Through the Multicomponent Reaction (MCR), an important tool in modern synthetic methodology, that generate products with good structural complexity, in addition to economy of atoms and selectivity, we provide easy access to the preparation of quinoline derivatives. The reactions were promoted by niobium pentachloride, as a Lewis acid. Subsequently, the synthesis of new aminoquinoline derivatives with good yields was performed using Pd/C and hydrazine. The photophysical investigations of quinoline derivatives show the substituent effect on the optical properties characterization was done by absorption and photoluminescence measurements with quantum yields of up to 83?%, the presence of the amino group at position 6 at the quinoline backbone was crucial for obtaining these increased quantum yields. Results show that these molecules may have potential use for a variety of applications and mainly attracts attention because of its wide potential of applicability in optoelectronic devices.

A multi-substituted quinoline synthetic method of compound

The invention relates to a synthetic method of a polysubstituted quinoline compound shown in the following formula (II). The method includes that a compound in the following formula (I) generates self cyclic reaction in a composite solvent under an inert atmosphere in the presence of catalysts, alkali and pyridine additives so as to obtain the compound in the formula (II), wherein R is C1-C6 alkyl, nitro or halogen, R1 and R2 are unsubstituted or substituent-bearing C1-C6 alkyl, unsubstituted or substituent-bearing phenyl or unsubstituted or substituent-bearing thienyl respectively and independently, and substituents are selected from C1-C6 alkyl or halogen. The catalyst, alkali, additive and composite solvent multicomponent reaction assist-catalysis system is adopted in the method, so that target products are obtained in high yield, and the method has good application prospect in the technical field of medical intermediate synthesis.

Oxidative povarov reaction via sp3 C-H oxidation of N-benzylanilines induced by catalytic radical cation salt: Synthesis of 2,4-diarylquinoline derivatives

Oxidative Povarov reaction of N-benzylanilines was realized under catalytic radical cation salt induced conditions. The mechanism studies revealed that a radical intermediate was involved in this catalytic oxidation. This method provides a new way to synthesize 2,4-diarylquinoline derivatives.

Synthesis of quinoline derivatives by multicomponent reaction using niobium pentachloride as lewis acid

The aim of this work was to investigate the use of NbCl5 as a Lewis acid in multicomponent reactions between benzaldehyde, aniline derivatives and phenylacetylene in the synthesis of quinoline derivatives. The effects of the temperature and substituents in the aromatic ring of the aniline were also evaluated. The reactions were carried out at low concentration of niobium and in relatively short reaction times, resulting in yields ranging from 67 to 96%.