13846-64-5

Upstream product

• 2168-78-7 methyl dithiobenzoate 
• 20602-62-4 Sodium; 2,2-dicyano-1-phenyl-ethenethiolate 
• 74-88-4 methyl iodide 
• 3189-43-3 tetracyanoethylene oxide 
• 77-78-1 dimethyl sulfate 
• 20770-25-6 Kalium-2-cyan-3-phenyl-acrylnitril-3-thiolat 

Downstream Products

• 196504-90-2 5-amino-1-benzyl-3-phenyl-1H-pyrazole-4-carbonitrile 
• 129852-40-0 1,3-Diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 
• 196505-09-6 (1-Benzyl-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-chloro-phenyl)-amine 
• 196505-06-3 1-Benzyl-4-chloro-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine 
• 196505-04-1 1-Benzyl-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol 
• 5515-31-1 5-amino-1,3-diphenylpyrazole-4-carbonitrile 
• 118349-45-4 5-amino-4-cyano-3-phenylyl-1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)pyrazole 
• 142232-02-8 2-Imino-6-methylthio-4-phenyl-1,2-dihydropyridin-1,3-dicarbonitril 
• 142386-62-7 Kalium-(2,2-dicyan-1-phenylvinyl)cyanamid 
• 118965-87-0 4-Amino-2-chlor-6-phenyl-pyrimidin-5-carbonitril 
• 71493-81-7 2-Amino-6-methylthio-4-phenyl-pyridin-3-carbonitril 

Relevant academic research and scientific papers

Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w

Polarized Ethylenes. IV. Synthesis of Polarized Ethylenes Using Thioamides and Methyl Dithiocarboxylates and their Application to Syntheses of Pyrazoles, Pyrimidines, Pyrazolopyrimidines, and 5-Azacyclazines

Polarized ethylenes having both electron-donating (an amino or a methylthio group) and electron-accepting (cyano, carbamoyl, methyl ester) groups on the adjacent two olefinic carbon atoms were prepared by the condensation of S-alkylthioamidinium salts or

SYNTHESIS OF NUCLEOSIDES USING KETENE DITHIOACETALS

Several unnatural pyrazole and 1,2,4-triazole nucleosides are synthesized in a regio- and stereoselective manner by the reaction of readily available ketene dithioacetals with 1-ribofuranosylhydrazine.

A NOVEL PREPARATION OF POLARIZED ETHYLENES BY THE REACTION OF THIOAMIDES OR DITHIOCARBOXYLATES WITH TETRACYANOETHYLENE OXIDE. SYNTHESIS OF PYRAZOLES AND PYRIMIDINES

Polarized ethylenes having both electron-donating (an amino or a methylthio group) and electron-accepting (two cyano groups) groups on the adjacent two olefinic carbon atoms were prepared by the reaction of thioamides or methyl dithiocarboxylates with tetracyanoethylene oxide in good yields.Reactions of these polarized ethylenes with hydrazine or guanidine carbonate gave the corresponding pyrazole and pyrimidine derivatives in good yields.