90495-99-1

Usage

Uses

Used in Pharmaceutical Industry:
2-[N-[2-(BOC-AMINO)ETHYL]AMINO]ACETIC ACID is used as a reagent in organic synthesis for the development of new drugs, owing to its ability to form larger molecules and contribute to the creation of potential therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 2-[N-[2-(BOC-AMINO)ETHYL]AMINO]ACETIC ACID is utilized as a component in the synthesis of complex organic compounds, facilitating the exploration of new chemical reactions and the discovery of novel chemical entities.
Used in Peptide Synthesis:
2-[N-[2-(BOC-AMINO)ETHYL]AMINO]ACETIC ACID is employed as a building block in peptide synthesis, allowing for the construction of specific peptide sequences that can be used in various applications, such as pharmaceuticals, diagnostics, and research tools.

Upstream product

• 174799-94-1 benzyl 2-(benzyl{2-[(tert-butoxycarbonyl)amino]ethyl}amino)acetate 
• 158663-62-8 N-((tert-butoxycarbonyl)-aminoethyl)glycine benzyl ester 
• 72648-80-7 ethyl 2-[2-(tert-butoxycarbonylamino)ethyl-[3-[[4-(4,5-difluoro-2-methylsulfanyl-phenyl)phenoxy]methyl]benzoyl]amino]acetate 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 79-11-8 chloroacetic acid 
• 24123-14-6 N-(2-Aminoethyl)glycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 174799-52-1 tert-butyl {2-[benzylamino]ethyl}carbamate 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 34046-07-6 N-benzyloxycarbonyl-N-(2-t.butoxycarbonylaminoethyl)glycine 
• 1025696-29-0 N-[2-(N-Boc)aminoethyl]-2-(4-dimethylaniline)-3,4-fulleropyrrolidine 
• 1025696-38-1 N-[2-(N-Boc)aminoethyl]-2-(5-(4-phenyl)-10,15,20-tris(3,5-di-tert-butylphenyl)porphyrin)zinc(II)-3,4-fulleropyrrolidine 
• 139166-80-6 N-(2-t-butoxycarbonylaminoethyl)-N-(thymin-1-ylacetyl)glycine 
• 406683-60-1 (E)-17-[N-[2-(tert-Butyloxycarbonylamino)ethyl]-N-fluorenylmethyloxycarbonylglycinyloxy]-4,7,10,13-tetraoxa-15-heptadecenoic acid phenacyl ester 
• 169287-77-8 Boc-PNA(G^Z)-OH 
• 141743-15-9 2-((((9H-fluoren-9-yl)methoxy)carbonyl)(2-((tert-butoxycarbonyl)amino)ethyl)amino)acetic acid 

Relevant academic research and scientific papers

Synthesis of camptothecin-amino acid carbamate linkers

A more convenient and facile approach for the synthesis and production of camptothecin-amino acids carbamate linkers, that can be used in the synthesis of bioconjugate peptides JF-10-81, JF-10-71, and other peptide analogs designed to target somatostatin receptors has been described. Springer-Verlag 2011.

Synthesis of 5-nitro-2-furancarbohydrazides and their cis- diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors

The human selenoprotein thioredoxin reductase is involved in antioxidant defense and DNA synthesis. As increased thioredoxin reductase levels are associated with drug sensitivity to cisplatin and drug resistance in tumor cells, this enzyme represents a promising target for the development of cytostatic agents. To optimize the potential of the widely used cisplatin to inhibit the human thioredoxin reductase and therefore to overcome cisplatin resistance, we developed and synthesized four cis-diamminedichloroplatinum complexes of the lead 5-nitro-2-furancarbohydrazide 8 selected from high-throughput screening. Detailed kinetics revealed that the isolated fragments, 5-nitro-2-furancarbohydrazide and cisplatin itself, bind with micromolar affinities at two different subsites of the human enzyme. By tethering both fragments four nitrofuran-based cis-diamminedichloroplatinum complexes 13a-c and 20 were synthesized and identified as biligand irreversible inhibitors of the human enzyme with nanomolar affinities. Studies with mutant enzymes clearly demonstrate the penultimate selenocysteine residue as the prime target of the synthesized cJs-diamminedichloroplatinum complexes.

Design, development and synthesis of a novel labeled PNA monomer incorporated in DNA-hexamer to act as a hybridization probe by FRET

A novel PNA monomer with adenine nucleobase and a modified backbone with charged -N+-H and a methylene substituted for 2 bond on the lefthand side sign C=O in the linker arm has been synthesised. This modified PNA monomer is further linked with

Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility

A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.

Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14)

The osteogenic growth peptide (OGP) is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury. When administered in vivo, OGP stimulates osteogenesis and hematopoiesis. The C-terminal pentapeptide OGP(10-14) is the minimal amino acid sequence that retains the full OGP-like activity. Apparently, it is also the physiologic active form of OGP. Residues Tyr10, Phe12, Gly13, and Gly14 of OGP are essential for the OGP(10-14) activity. The present study explored the functional role of the peptide bonds, carboxyl and amino terminal groups, and conformational freedom in OGP(10-14). Transformations replacing the peptide bonds with surrogates such as ψ(CH2NH), ψ(CONMe), and ψ(CH2CH2) demonstrated that amide bonds do not contribute significantly to OGP(10-14) bioactivity. End-to-end cyclization yielded the fully bioactive cyclic pentapeptide c(Tyr-Gly-Phe-Gly-Gly). The retroinverso analogue c(Gly-Gly-phe-Gly-tyr), a cyclostereoisomer of c(Tyr-Gly-Phe-Gly-Gly), is at least as potent as the parent cyclic pentapeptide. The unique structure-activity relations revealed in this study suggest that the spatial presentation of the Tyr and Phe side chains has a major role in the productive interaction of OGP(10-14) and its truncated and conformationally constrained analogues with their cognate cellular target.

Peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.

PEPTIDE NUCLEIC ACID CONJUGATES

A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Peptide nucleic acids having 2,6-diaminopurine nucleobases

A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8alkylamine side chains.

Double-stranded peptide nucleic acids

A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Novel versatile fullerene synthons

We report the synthesis of three novel, versatile fullerene intermediates whose main feature is the presence of an amino end group. Simple condensation reactions of these intermediates under standard conditions produce new derivatives that are useful for