139237-77-7

Usage

Uses

Used in Pharmaceutical Industry:
(R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE is used as a potential therapeutic agent for the treatment of neurodegenerative disorders and cancer. Its unique structural features and potential therapeutic properties make it a promising candidate for further research and development in the pharmaceutical field.
Used in Antimicrobial Applications:
In the field of microbiology, (R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE is used as an antimicrobial agent. Its potential to combat various pathogens makes it a valuable compound for research and development in the area of infectious diseases and public health.
Used in Research and Development:
(R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE is utilized as a subject of ongoing scientific research, particularly in the fields of chemistry, biology, and medicine. Its unique structural features and potential applications in various therapeutic areas make it an important compound for further exploration and understanding of its properties and capabilities.

Upstream product

• 75-15-0 carbon disulfide 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 67-68-5 dimethyl sulfoxide 
• 694-83-7 rac-diaminocyclohexane 
• 1436-59-5 cis-cyclohexane-1,2-diamine 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 137618-01-0 1,3-di(2-benzylbutanoyl)-trans-4,5-tetramethyleneimidazolidine-2-thione 
• 137638-30-3 1,3-di(2-benzylbutanoyl)-trans-4,5-diphenylimidazolidine-2-thione 
• 137638-29-0 1,3-di(3-phenylpropionyl)-trans-4,5-tetramethyleneimidazolidine-2-thione 
• 137618-00-9 1,3-di(3-phenyl-2-methylpropionyl)-trans-4,5-tetramethyleneimidazolidine-2-thione 
• 137618-14-5 1,3-di(3-phenylpropionyl)-trans-4,5-tetramethyleneimidazolidin-2-one 
• 77006-52-1 (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride 
• 64107-71-7 (4aR,8aR)-3-Methyl-4a,5,6,7,8,8a-hexahydro-benzo[4,5]imidazo[2,1-b]thiazole; hydrochloride 
• 64107-71-7 (4aR,8aS)-3-Methyl-4a,5,6,7,8,8a-hexahydro-benzo[4,5]imidazo[2,1-b]thiazole; hydrochloride 
• 137618-17-8 (3aR,7aR)-1,3-Bis-(2-benzyl-butyryl)-octahydro-benzoimidazol-2-one 
• 139122-14-8 (3aR,7aR)-1,3-Bis-(2-methyl-3-phenyl-propionyl)-octahydro-benzoimidazol-2-one 
• 137618-18-9 (3aS,7aS)-1,3-Bis-[(E)-(3-phenyl-acryloyl)]-octahydro-benzoimidazol-2-one 
• 137618-03-2 1,3-dioctadecanoyl-trans-4,5-tetramethyleneimidazoline-2-thione 
• 137618-02-1 (E)-3-Phenyl-1-{(3aS,7aS)-3-[(E)-(3-phenyl-acryloyl)]-2-thioxo-octahydro-benzoimidazol-1-yl}-propenone 

Relevant academic research and scientific papers

IMIDAZOLINE DERIVATIVES AS CXCR4 MODULATORS

The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds of formula (I) can act as CXCR4 modulators that specifically target the CXCR4 minor pocket, and they have further been

A catalyst-free and additive-free method for the synthesis of benzothiazolethiones from: O -iodoanilines, DMSO and potassium sulfide

Under catalyst-free and additive-free conditions, a novel, convenient, eco-friendly method for the synthesis of benzothiazolethiones has been developed. The three-component reaction of o-iodoanilines and K2S with DMSO proceeded smoothly and the corresponding benzothiazolethiones were obtained with good isolated yields. Meanwhile, this method could be used for the synthesis of thioureas from primary diamines. Furthermore, mechanism research showed that DMSO not only functioned as a carbon source, but also as a mild oxidant in this reaction.

Bifunctional Chiral Auxiliaries 5: The Synthesis of 1,3-Diacylimidazolidine-2-thiones and 1,3-Diacylimidazolidin-2-ones from 1,2-Diamines

Although 1,2-diamines fail to cyclise with urea, phosgene or 1,1'-carbonyl diimidazole, they react with carbon disulphide to give the corresponding imidazolidine-2-thiones.These undergo clean diacylation to give 1,3-diacylimidazolidine-2-thiones which are

Bifunctional chiral auxiliaries 2: The synthesis of 1,3-diacylimidazolidin-2-ones from 1,2-diamines

The title compounds are readily prepared in three steps via the corresponding 1,3-diacylimidazolidine-2-thiones. The final step involves the novel use of mercury (II) acetate for the conversion of thioureas to ureas.

Effect of Structural Change on Acute Toxicity and Antiinflammatory Activity in a Series of Imidazothiazoles and Thiazolobenzimidazoles

The effect of structural change on the biological activity of a series of imidazothiazoles and thiazolobenzimidazoles is described.It was found that compounds with polar substituents at the 2 or 3 position of the ring system are less acutely toxic while maintaining antiinflammatory activity.Other structural changes, such as the incorporation of a gem-dimethyl substituent in the 6 position, increase acute toxicity and eliminate antiinflammatory activity.The compound with the best activity/toxicity ratio contains an alkyl sulfonyl substituent on the thiazole ring.The thiazolobenzimidazole analogues are more potent than the imidazole analogues.