139237-77-7

Basic information

• Product Name: (R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE
• Synonyms: (R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE
• CAS NO: 139237-77-7
• Molecular Formula: C₇H₁₂N₂S
• Molecular Weight: 156.24858
• Mol File: 139237-77-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: (R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE(139237-77-7)
• EPA Substance Registry System: (R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE(139237-77-7)

Safety Data

• Hazardous Substances Data: 139237-77-7(Hazardous Substances Data)

Usage

General Description

(R,R)-OCTAHYDRO-BENZOIMIDAZOLE-2-THIONE is a chemical compound with potential pharmaceutical and biological applications. It is a derivative of benzimidazole, a heterocyclic compound, and contains a thione functional group. The compound has been studied for its potential use in the treatment of various diseases, including neurodegenerative disorders and cancer. It has also been investigated for its antimicrobial properties. The compound is of interest to researchers due to its unique structural features and potential therapeutic properties, making it a subject of ongoing scientific research.

Upstream product

• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 75-15-0 carbon disulfide 
• 1436-59-5 cis-cyclohexane-1,2-diamine 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 67-68-5 dimethyl sulfoxide 
• 694-83-7 rac-diaminocyclohexane 

Downstream Products

• 137618-02-1 (E)-3-Phenyl-1-{(3aS,7aS)-3-[(E)-(3-phenyl-acryloyl)]-2-thioxo-octahydro-benzoimidazol-1-yl}-propenone 
• 137618-17-8 (3aR,7aR)-1,3-Bis-(2-benzyl-butyryl)-octahydro-benzoimidazol-2-one 
• 139122-14-8 (3aR,7aR)-1,3-Bis-(2-methyl-3-phenyl-propionyl)-octahydro-benzoimidazol-2-one 
• 137618-18-9 (3aS,7aS)-1,3-Bis-[(E)-(3-phenyl-acryloyl)]-octahydro-benzoimidazol-2-one 
• 137618-14-5 1,3-di(3-phenylpropionyl)-trans-4,5-tetramethyleneimidazolidin-2-one 
• 64107-71-7 (4aR,8aS)-3-Methyl-4a,5,6,7,8,8a-hexahydro-benzo[4,5]imidazo[2,1-b]thiazole; hydrochloride 
• 64107-71-7 (4aR,8aR)-3-Methyl-4a,5,6,7,8,8a-hexahydro-benzo[4,5]imidazo[2,1-b]thiazole; hydrochloride 
• 137638-29-0 1,3-di(3-phenylpropionyl)-trans-4,5-tetramethyleneimidazolidine-2-thione 
• 137618-00-9 1,3-di(3-phenyl-2-methylpropionyl)-trans-4,5-tetramethyleneimidazolidine-2-thione 
• 137618-03-2 1,3-dioctadecanoyl-trans-4,5-tetramethyleneimidazoline-2-thione 
• 77006-52-1 (4aR,8aR)-2,2-Dimethyl-3-phenyl-2,3,4a,5,6,7,8,8a-octahydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol; hydrochloride 
• 137638-30-3 1,3-di(2-benzylbutanoyl)-trans-4,5-diphenylimidazolidine-2-thione 
• 137618-01-0 1,3-di(2-benzylbutanoyl)-trans-4,5-tetramethyleneimidazolidine-2-thione 

Relevant articles and documents

IMIDAZOLINE DERIVATIVES AS CXCR4 MODULATORS

The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds of formula (I) can act as CXCR4 modulators that specifically target the CXCR4 minor pocket, and they have further been

Bifunctional Chiral Auxiliaries 5: The Synthesis of 1,3-Diacylimidazolidine-2-thiones and 1,3-Diacylimidazolidin-2-ones from 1,2-Diamines

Although 1,2-diamines fail to cyclise with urea, phosgene or 1,1'-carbonyl diimidazole, they react with carbon disulphide to give the corresponding imidazolidine-2-thiones.These undergo clean diacylation to give 1,3-diacylimidazolidine-2-thiones which are

Effect of Structural Change on Acute Toxicity and Antiinflammatory Activity in a Series of Imidazothiazoles and Thiazolobenzimidazoles

The effect of structural change on the biological activity of a series of imidazothiazoles and thiazolobenzimidazoles is described.It was found that compounds with polar substituents at the 2 or 3 position of the ring system are less acutely toxic while maintaining antiinflammatory activity.Other structural changes, such as the incorporation of a gem-dimethyl substituent in the 6 position, increase acute toxicity and eliminate antiinflammatory activity.The compound with the best activity/toxicity ratio contains an alkyl sulfonyl substituent on the thiazole ring.The thiazolobenzimidazole analogues are more potent than the imidazole analogues.