139243-54-2

Basic information

• Product Name: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride, (R)-
• Synonyms: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride, (R)-;METHYL (R)-HOMO-BETA-ALANINATE HCL;(R)-3-aminobutanoic acid methyl ester hydrochloride;R-3-ABU-OME HCl;(R)-3-AMINO-BUTYRIC ACID METHYL ESTER HCl;(R)-Methyl 3-aminobutanoate hydrochloride;Methyl (R)-3-Aminobutanoate Hydrochloride
• CAS NO: 139243-54-2
• Molecular Formula: C₅H₁₁NO₂*ClH
• Molecular Weight: 153.60728
• Product Categories: 6
• Mol File: 139243-54-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride, (R)-(139243-54-2)
• EPA Substance Registry System: Butanoic acid, 3-aMino-, Methyl ester, hydrochloride, (R)-(139243-54-2)

Safety Data

• Hazardous Substances Data: 139243-54-2(Hazardous Substances Data)

Usage

General Description

Butanoic acid, 3-amino-, methyl ester, hydrochloride, (R)- is a chemical compound that consists of a methyl ester of 3-amino butanoic acid, which is a derivative of butanoic acid. Butanoic acid, 3-aMino-, Methyl ester, hydrochloride, (R)- exists in its hydrochloride form and is optically active, with its (R)-enantiomer being the predominant form. It is commonly used as a pharmaceutical intermediate and as a building block in the synthesis of various organic compounds. This chemical may have various applications in the pharmaceutical and chemical industries, including as a precursor in the synthesis of pharmaceutical drugs and as a ligand in chemical catalysis.

Upstream product

• 137132-12-8 (3RS)-3-aminobutanoic acid methyl ester hydrochloride 
• 108-59-8 malonic acid dimethyl ester 
• 3775-73-3 (R)-3-aminobutanoic acid 
• 67-56-1 methanol 
• 121054-32-8 3(R)-benzamidobutanoic acid methyl ester 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 61477-40-5 (R)-3-amino-1-butanol 
• 142035-70-9 methyl (R)-3-(benzyloxycarbonylamino)-butanoate 
• 121054-32-8 3(R)-benzamidobutanoic acid methyl ester 
• 159877-47-1 methyl 3-(R)-[N-(tert-butoxycarbonyl)amino]-propanoate 
• 161688-97-7 (R)-3-aminobutanoic acid methyl ester 

Relevant articles and documents

Extracting preparing method for R-3-Aminobutanol

The invention relates to an extracting preparing method for R-3-Aminobutanol. R-3-aminobutyric acid is adopted as a raw material, an esterification reaction is performed to obtain R-3-amino-crotonic acid ester, then, a reduction reaction, resin extraction and an alkali reaction performed to obtain the R-3-Aminobutanol with high quality and purity is obtained. The method has the advantages of recycling resin, reducing the waste salt and waste residue generation amount, being high in yield and product quality and the like, the problem that products are not directly extracted from water easily issuccessfully solved, and the problems that a traditional technology is large in water steam energy consumption and not sufficient in solvent extraction are solved.

A 3 (R) / (S)-amino-1-butanol method for the preparation of

The invention provides a method for preparing 3(R)/(S)-amidogen-1-butanol. The method comprises the steps that firstly, benzamide reacts with acetoacetic ester under the catalyzing action of p-toluenesulfonic acid, so that 3-benzamido-2-butene acid ester is generated; secondly, catalytic hydrogenation is conducted by using a chiral rhodium-diphosphine ligand compound as a catalyst for enantioselective hydrogenation, so that 3(R)/(S)-benzamide butyrate is generated highly selectively; thirdly, benzoyl is removed by means of mixed solvent of concentrated hydrochloric acid and alcohol, so that 3(R)/(S)-amino-crotonic acid ester hydrochloride is generated; finally, optically pure 3(R)/(S)-amidogen-1-butanol is obtained after ester carbonyl is reduced by means of hydronoron. According to the method, the raw materials are low in cost and easy to obtain, the technological operation is easy and convenient, resolution is not needed, the yield is high, cost is low, environmental friendliness is achieved, the optical purity of product is high, and the method is more suitable for industrial production.

Enantioselective Synthesis of β-Amino Acids. 2. Preparation of the like Stereoisomers of 2-Methyl- and 2-Benzyl-3-aminobutanoic Acid

An improved procedure for the preparation of (R)- and (S)-3-aminobutanoic acids (2a) through diastereomer separation of the corresponding (1'S)-N-phenethyl derivatives 1 is reported.From 2a, the four possible stereoisomeric perhydropyrimidin-4-ones 4 were prepared through the amide 2c and the Schiff base 3.In the cyclization of 3, the cis products 4 predominate ca. 95:5.These heterocycles can be alkylated (LDA, RX), as demonstrated by methylation and benzylation, with formation of a single diastereoisomer (5, 6).Hydrolysis (6 N aqueous HCl) of these 5,6-dialkylperhydropyrimidin-4-ones leads to the free amino acids 7-10.