145902-56-3

Upstream product

• 2748-02-9 L-leucine tert-butyl ester hydrochloride 
• 139397-07-2 (4R,5S)-4-benzyl-3-[(tert-butoxy)carbonyl]-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid 
• 204460-76-4 (4R,5S)-4-Benzyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester 
• 81926-51-4 N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 77119-85-8 N-(tert-butoxycarbonyl)-D-phenylalaninal 
• 19901-50-9 methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 65391-42-6 Bestatin hydrochloride 
• 223763-80-2 bestatin trifluroacetate salt 
• 114886-76-9 (2(S)-hydroxy-3(R)-amino-4-phenylthiobutanoyl)-L-leucine trifluoroacetate 

Relevant academic research and scientific papers

A practical diastereoselective synthesis of (?)-bestatin

Diastereoselective addition of nitromethane to Boc-D-Phe-H in the presence of sodium hydride in diethyl ether/hexane containing 15-crown-5 and subsequent N,O-protection with 2,2-dimethoxypropane gave trans-oxazolidine in a diastereomeric ratio of >16:1. T

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh