1394168-98-9

Basic information

• Product Name: di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate
• Synonyms: di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate
• CAS NO: 1394168-98-9
• Molecular Weight: 490.617
• Mol File: 1394168-98-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate(1394168-98-9)
• EPA Substance Registry System: di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate(1394168-98-9)

Safety Data

• Hazardous Substances Data: 1394168-98-9(Hazardous Substances Data)

Upstream product

• 74590-67-3 ethyl 2-fluoro-2-(4-isobutylphenyl)propanoate 
• 62784-66-1 bis(1-naphthyl)methanol 
• 180293-49-6 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionic acid 
• 15687-27-1 ibuprofen 
• 41283-72-1 ibuprofen ethyl ester 

Relevant articles and documents

A new method for production of chiral 2-aryl-2-fluoropropanoic acids using an effective kinetic resolution of racemic 2-aryl-2-fluoropropanoic acids

We report a new method for the preparation of chiral 2-aryl-2- fluoropropanoic acids, including 2-fluoroibuprofen, a fluorinated analogue of non-steroidal anti-inflammatory drugs (NSAIDs), by the kinetic resolution of racemic 2-aryl-2-fluoropropanoic acids using enantioselective esterification. By applying pivalic anhydride (Piv2O) as a coupling agent, bis(α-naphthyl)methanol [(α-Np)2CHOH] as an achiral alcohol, and (+)-benzotetramisole (BTM) as a chiral acyl-transfer catalyst, a series of racemic 2-aryl-2-fluoropropanoic acids were kinetically separated to afford the optically active carboxylic acids and the corresponding esters with good to high enantiomeric excesses. This technology can provide a convenient approach to furnish the chiral a-fluorinated drugs containing quaternary carbons at the α-positions in the 2-aryl-2-fluoropropanoic acid structure.