139481-38-2

Basic information

• Product Name: Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate
• Synonyms: 2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)Methyl][(1,1-diMethylethoxy)carbonyl]aMino]-3-nitrobenzoic Acid Methyl Ester;Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate;Azilsartan pharMaceutical interMediate;Azilsartan PI-1
• CAS NO: 139481-38-2
• Molecular Formula: C₂₇H₂₅N₃O₆
• Molecular Weight: 487.5039
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 139481-38-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate(139481-38-2)
• EPA Substance Registry System: Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate(139481-38-2)

Safety Data

• Hazardous Substances Data: 139481-38-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Upstream product

• 73833-13-3 acid chloride of 1-methylhydrogen-3-nitrophthalate 
• 603-11-2 3-nitrophthalic acid 
• 209911-63-7 2-(4,4-dibromomethylphenyl)benzonitrile 
• 57113-90-3 methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate 
• 856414-36-3 2-Azidocarbonyl-3-nitro-benzoic acid methyl ester 
• 21606-04-2 methyl 2-carboxy-3-nitrobenzoate 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 

Downstream Products

• 139481-28-0 methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate 
• 139481-59-7 candesartan 
• 139482-06-7 3-[2'-(1H-Tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2,2,2-trifluoro-ethoxy)-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-97-3 2-Morpholin-4-yl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-98-4 2-Piperidin-1-yl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-96-2 2-Butylamino-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 136284-88-3 2-Ethylsulfanylmethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-71-3 2-Propylamino-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-65-5 2-Propylsulfanyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-60-0 ethyl 2-Propoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 
• 136285-07-9 Methyl 2-(2-methylthioethyl)-1-[[2'-(1H-tetrazol-5-yl]biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 
• 136285-06-8 Methyl 2-(2-methoxyethyl)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 
• 136285-02-4 ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate 
• 136285-00-2 2-Ethoxymethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 

Relevant articles and documents

CRYSTAL AND PROCESS FOR PRODUCING THE SAME

A process for producing crystals of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.