139592-86-2Relevant academic research and scientific papers
Cu-Catalyzed highly regioselective 1,2-hydrocarboxylation of 1,3-dienes with CO2
Zhang, Penglin,Zhou, Zhanglang,Zhang, Rumeng,Zhao, Qian,Zhang, Chun
, p. 11469 - 11472 (2020)
A practical copper-catalyzed highly regioselective 1,2-hydrocarboxylation of terminal 1,3-diene with carbon dioxide has been developed. Under mild reaction conditions, this chemistry afforded 2-benzyl-β,γ-unsaturated acid derivatives as products, which are a kind of important unit for bio-active molecules and versatile precursors for organic synthesis, with good functional group tolerance. The key intermediate in this transformation is illustrated by control experiments.
The studies on the chemoenzymatic synthesis of 2-benzyl-3-butenoic acid
Borys, Filip,Paprocki, Daniel,Koszelewski, Dominik,Ostaszewski, Ryszard
, p. 6 - 9 (2018/06/01)
The studies on the chemoenzymatic synthesis of 2-benzyl-3-butenoic acid 3 were performed. The alkylation of dienolates derived from the crotonic and vinylacetic acids with different types of alkylating agents was examined. In all cases the inseparable mixture of isomeric acids 3 and 4 were obtained. Chemoselective enzymatic esterification of those mixtures provides ester 6 in 86% yield as a single product without double bond isomerization. None common method can be used for its hydrolysis since under basic conditions only isomeric acid 5 is formed. To overcome this limitation enzyme catalysed hydrolysis process was design. This protocol afforded isomerically pure acid 3 in 98% yield.
The Stereochemistry of Ring Closure of Some Monosubstituted o-(But-3-enyl)phenyl Radicals
Beckwith, Athelstan L. J.,Gerba, Sendaba
, p. 289 - 308 (2007/10/02)
The rates and diastereoselectivity of cyclization of o-(but-3-enyl)phenyl radicals bearing substituents on the 1- or 2-position of the side chain have been examined. 1-Substituted radicals afford only 1,5-cyclization products, but 2-substituted radicals a
