13996-08-2

Upstream product

• 64502-69-8 3,5-diphenyl-1,2,4-dithiazol-1-ium perchlorate 
• 109-77-3 malononitrile 
• 42754-56-3 2-(methoxyphenylmethylene)malononitrile 
• 2227-79-4 benzenecarbothioamide 
• 60776-91-2 2-(ethoxy(phenyl)methylene)malononitrile 
• 16187-90-9 β-imino-β-phenylpropionitrile 
• 69143-56-2 5-methylsulphonyl-4-phenyl-1,3-thiazine-2,6(3H)-dithione 
• 69143-65-3 4-phenyl-5-phenylsulphonyl-1,3-thiazine-2,6(3H)-dithione 
• 96530-65-3 2-Cyano-3-phenyl-3-thiobenzamidopropenenitrile 
• 104-94-9 4-methoxy-aniline 
• 737-53-1 4-chloro-2,6-diphenylpyrimidine-5-carbonyltrile 

Downstream Products

• 866111-66-2 2-(5-cyano-2,6-diphenyl-pyrimidin-4-ylsulfanyl)-acetamide 
• 96530-64-2 bis-(5-Cyano-2,6-diphenyl-4-pyrimidinyl) Disulfide 
• 64499-36-1 4-(4-Methoxyphenylamino)-2,6-diphenyl-5-pyrimidincarbonitril 
• 194477-07-1 3-amino-2-cyano-4,6-diphenylthieno[2,3-d]pyrimidine 
• 194477-08-2 3-amino-2-(4,5-dihydro-1H-imidazol-2-yl)-4,6-diphenylthieno[2,3-d]pyrimidine 
• 194477-15-1 7,9-diphenyl-2,3-dihydroimidazo[1,2-c]pyrimido[5',4':4,5]thieno[2,3-e]pyrimidine-5(6H)thione 
• 194477-28-6 7,9-diphenyl-5-hydrazino-2,3-dihydroimidazo[1,2-c]pyrimido[5',4':4,5]thieno[2,3-e]pyrimidine 
• 866111-80-0 C₃₀H₂₂N₆OS₂ 

Relevant academic research and scientific papers

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair

The enzyme 15-prostaglandin dehydrogenase (15-PGDH) catalyzes the first step in the degradation of prostaglandins including PGE2. It is a negative regulator of tissue repair and regeneration in multiple organs. Accordingly, inhibitors of 15-PGDH are anticipated to elevate in vivo levels of PGE2 and to promote healing and tissue regeneration. The small molecule SW033291 (1) inhibits 15-PGDH with Ki = 0.1 nM in vitro, doubles PGE2 levels in vivo, and shows efficacy in mouse models of recovery from bone marrow transplantation, ulcerative colitis, and partial hepatectomy. Here we describe optimized variants of 1 with improved solubility, druglike properties, and in vivo activity.

COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

Synthesis of Pyrimidine Derivatives Having Oxo, Thioxo or Amino Functions at Position 4 from 1,2,4-Dithiazolium Salts

The (thioaroylamido)acrylonitriles 2, obtained by reaction of 1,2,4-dithiazolium salts 1 with ethyl cyanacetate, undergo ring tranformation reactions by reaction with ammonium acetate, primary and secondary amines and form the pyrimidines 7-9.A possible mechanism for these reactions is discussed.

Synthesis of Heterocyclic Compounds. XXXIX. Synthesis of 5-Cyano-2-phenyl-4-thioxo-3,4-dihydropyrimidines

The reaction of thiobenzamide with 3-alkoxy-3-aryl(or alkyl)-2-cyanopropenenitriles 1 and sodium 2-propoxide in 2-propanol afforded after acidic treatment 6-aryl(or alkyl)-5-cyano-2-phenyl-4-thioxo-3,4-dihydropyrimidines 3 through formation of the 3-aryl(

The Reaction of 3,5-Diphenyl-1,2,4-dithiazol-1-ium Perchlorate with Active Methylene Compounds

The reaction of 3,5-diphenyl-1,2,4-dithiazol-1-ium perchlorate with several kinds of active methylenes gives a number of heterocycles, such as 4-hydroxy and 4-mercaptopyrimidine, pyrimidinone, and thiazole derivatives.On treatment with hydroxylamine-O-sulfonic acid, the 4-mercaptopyrimidines lead to the aminothio compounds or the isothiazolopyrimidine.

The Reaction of 2,4,6-Triphenyl-1,3,5-thiadiazin-1-ium Salt with Active Methylene Compounds

The reaction of 2,4,6-triphenyl-1,3,5-thiadiazin-1-ium tetrafluoroborate with several active methylene compounds was studied.Nitromethane and nitroethane gave 2H-1,3,5-thiadiazines.The compounds possessing a benzoyl group reacted with this salt to give 5-