161646-54-4

Upstream product

• 106-95-6 allyl bromide 
• 161646-53-3 tert-butyl (4-(benzyloxy)-1-iodonaphthalen-2-yl)carbamate 
• 139975-98-7 tert-butyl-(4-hydroxynaphthalen-2-yl)carbamate 
• 501440-80-8 3-(N-tert-butyloxycarbonyl)amino-1-O-(tertbutyloxycarbonyl)-1-naphthol 
• 2764-95-6 4-methoxy-2-naphthylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 122745-36-2 N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine 

Downstream Products

• 161646-55-5 5-(Benzyloxy)-3-(tert-butyloxycarbonyl)-1-<<(2',2',6',6'-tetramethylpiperidino)oxy>methyl>-1,2-dihydro-3H-benzindole 
• 244154-66-3 tert-butyl (S)-1-(chloromethyl)-5-((4-methylpiperazine-1-carbonyl)oxy)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 130008-89-8 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole 
• 122745-40-8 tert-Butyl(S)-5-(benzyloxy)-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 122745-41-9 tert-butyl (1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 122745-39-5 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole 

Relevant academic research and scientific papers

An efficient synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI): An enhanced and simplified analog of the CC-1065 and duocarmycin alkylation subunits

An efficient synthesis of 4, the immediate precursor to N-BOC-CBI and related analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[c]indol-4-one alkylation subunit, is described based on a Tempo trap of a 5-exo-trig aryl radical-alken

ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS

Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.