25021-49-2

Basic information

• Product Name: 4-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE
• Synonyms: TIMTEC-BB SBB010835;CHEMBRDG-BB 4102368;IFLAB-BB F1912-0014;ASINEX-REAG BAS 10155523;4-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE;4-(2-METHYL-1,3-THIAZOL-4-YL)PHENYLAMINE;4-(2-METHYL-THIAZOL-4-YL)-PHENYLAMINE;2-methyl-4-(4-aminophenyl)thiazole
• CAS NO: 25021-49-2
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.26
• Mol File: 25021-49-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 133-135 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 346.1 °C at 760 mmHg
• Flash Point: 163.1 °C
• Appearance: /
• Density: 1.219 g/cm³
• Vapor Pressure: 5.88E-05mmHg at 25°C
• Refractive Index: 1.642
• PKA: 3.51±0.10(Predicted)
• CAS DataBase Reference: 4-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE(25021-49-2)
• EPA Substance Registry System: 4-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE(25021-49-2)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 25021-49-2(Hazardous Substances Data)

Usage

Uses

4-(2-Methyl-1,3-thiazol-4-yl)aniline is used to synthesize and characterize 3''-?(4-?(2-?substituted thiazol-?4-?yl)?phenyl)?spiro[indoline-?3,?2''-?thiazolidine]?-?2,?4''-?diones, which showed good antimicrobial activity.

InChI:InChI=1/C10H10N2S/c1-7-12-10(6-13-7)8-2-4-9(11)5-3-8/h2-6H,11H2,1H3

Upstream product

• 33102-81-7 2-methyl-4-(4-nitrophenyl)thiazole 
• 99-81-0 4-Nitrophenacyl bromide 
• 7647-01-0 hydrogenchloride 
• 65321-91-7 N-[4-(2-methyl-4-thiazolyl)phenyl]acetamide 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 99-92-3 p-aminobenzophenone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 21675-02-5 4-acetylaminophenacyl bromide 
• 1826-16-0 2-methyl-4-phenylthiazole 
• 2631-71-2 4-aminophenacyl chloride 
• 62-55-5 thioacetamide 
• 140-49-8 N-[4-(chloroacetyl)phenyl]acetamide 

Downstream Products

• 325988-96-3 [4-(2-methyl-thiazol-4-yl)-phenyl]-carbamic acid phenyl ester 
• 65321-94-0 2-(4-dimethylamino-styryl)-3-methyl-4-[4-(triphenyl-λ⁵-phosphanylideneamino)-phenyl]-thiazolium; iodide 
• 65321-95-1 1-[4-(2-methyl-thiazol-4-yl)-phenyl]-5-p-tolyl-1H-[1,2,3]triazole 
• 75150-39-9 4-amino-N-[4-(2-methyl-thiazol-4-yl)-phenyl]-benzenesulfonamide 
• 75129-49-6 4-amino-N-[6-(2-methyl-thiazol-4-yl)-benzothiazol-2-yl]-benzenesulfonamide 
• 75129-48-5 4-acetylamino-N-[6-(2-methyl-thiazol-4-yl)-benzothiazol-2-yl]-benzenesulfonamide 
• 75129-23-6 [4-(2-methyl-thiazol-4-yl)-phenyl]-thiourea 
• 1262444-24-5 5-chloro-3'-(4-(2-methylthiazol-4-yl)phenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione 
• 1350661-77-6 N-(4-(2-methylthiazol-4-yl)phenyl)-2-(2,4-dichlorobenzyl)-4-methylthiazole-5-carboxamide 
• 1350661-82-3 N-(4-(2-methylthiazol-4-yl)phenyl)-2-(4-fluorobenzyl)-4-methylthiazole-5-carboxamide 
• 1350661-86-7 N-(4-(2-methylthiazol-4-yl)phenyl)-2-(4-chlorobenzyl)-4-methylthiazole-5-carboxamide 
• 1229016-75-4 2-[4-(2-methylthiazol-4-yl)phenylamino]-6-chloro-3-nitropyridine 
• 1229014-76-9 2-[4-(2-methylthiazol-4-yl)phenylamino]-6-(methylamino)-3-nitropyridine 

Relevant articles and documents

Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by spectral data (IR, 1H NMR, 13C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a-j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50values ranging between 30 and 403 μg/mL.

Synthesis and antimicrobial activities of novel series of 3-(4-(2-substituted thiazol-4-yl)phenyl)-2-(4-methyl-2-substituted thiazol-5-yl)thiazolidin-4-one derivatives

In the present investigation, a novel series of 3-(4-(2-substituted thiazol-4-yl)phenyl)-2-(4-methyl-2-substituted thiazol-5-yl)thiazolidin-4-one derivatives were synthesized by condensation of 2-substituted-4-methylthiazole- 5-carbaldehyde with 4-(2-subs

NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME

The present invention relates to a novel 2,6-substituted-3-nitropyridine derivative compound, a method for preparing the same, and a pharmaceutical composition including the same for prevention and treatment of osteoporosis. The 2,6-substituted-3-nitropyr