1401103-71-6Relevant articles and documents
Scale-up synthesis of a deuterium-labeled cis-cyclobutane-1,3-Dicarboxylic acid derivative using continuous photo flow chemistry
Yamashita, Toshiro,Nishikawa, Hitoaki,Kawamoto, Tetsuji
, p. 617 - 623 (2019/01/05)
Continuous photo flow synthesis of tert-butyl 3-oxo-2-oxabicyclo[2.2.0]hex-5-ene-6-carboxylate (2b) from tert-butyl 2-oxo-2H-pyran-5-carboxylate (1b) has been investigated for scale-up synthesis of cis-3-(tert-butoxycarbonyl)-2,3,4-d3-cyclobuta
Applications of C-H functionalization logic to cyclobutane synthesis
Gutekunst, Will R.,Baran, Phil S.
, p. 2430 - 2452 (2014/04/17)
The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H functionalization of cyclobutanes.
Sequential Csp3-H arylation and olefination: Total synthesis of the proposed structure of pipercyclobutanamide a
Gutekunst, Will R.,Gianatassio, Ryan,Baran, Phil S.
supporting information; experimental part, p. 7507 - 7510 (2012/09/10)
Hip to be square: A strategy for assembling tetrasubstituted cyclobutanes is reported in the context of a short, protecting-group-free synthesis of the proposed structure of pipercyclobutanamide A. The route features sequential C-H functionalizations on an unactivated cyclobutane wherein C-C bonds to aryl and styryl groups are made one by one in a stereocontrolled fashion. DG=directing group. Copyright
