1404471-72-2Relevant academic research and scientific papers
Regio- And chemo-selective cyclization of allenic-Ugi products for the synthesis of 3-pyrroline skeletons
Amiri, Kamran,Khosravi, Hormoz,Balalaie, Saeed,Golmohammadi, Farhad,Anwar, Muhammad U.,Al-Harrasi, Ahmed
, p. 8858 - 8870 (2019)
A highly efficient and stable novel class of allenic-Ugi products through a Crabbé homologation reaction is successfully demonstrated. Then, a regio- and chemo-selective cyclization of allenic-Ugi derivatives in a 5-exo-dig fashion to access 3-pyrroline skeletons is developed. Also, computational studies were performed and explained to provide insights into the reaction mechanism. This approach displays high bond-forming efficiency and atom economy with high yields.
Synthesis of Ugi 4-CR and Passerini 3-CR Adducts under Mechanochemical Activation
Polindara-García, Luis A.,Juaristi, Eusebio
supporting information, p. 1095 - 1102 (2016/03/05)
The successful application of a mechanochemical activation strategy that employs high-speed ball milling (HSBM) conditions for isocyanide-based multicomponent reactions (IMCRs) was developed. The syntheses of valuable Ugi (by a liquid-assisted grinding process) and Passerini (under solvent-free conditions) adducts were achieved by using this method. The protocol disclosed herein allows for the modular synthesis of various compounds according to green chemistry principles, specifically, environmentally friendly conditions, high atom economy, and the absence of toxic byproducts.
Two-step synthesis of 2,3-dihydropyrroles via a formal 5-endo cycloisomerization of Ugi 4-CR/propargyl adducts
Polindara-Garcia, Luis A.,Miranda, Luis D.
supporting information, p. 5408 - 5411,4 (2012/12/12)
A practical two-step synthesis of 2,3-dihydropyrroles from Ugi 4-CR/propargyl adducts is presented. The protocol includes a base-mediated formation of an allenamide functional group and an in situ metal-free formal 5-endo cycloisomerization that occurs in a highly regioselective manner at the allenamide C-γ.
