191092-08-7

Basic information

• Product Name: (R)-3-(Tosyloxymethyl)-N-Boc-piperidine
• Synonyms: (R)-3-(Tosyloxymethyl)-N-Boc-piperidine
• CAS NO: 191092-08-7
• Molecular Formula: C₁₈H₂₇NO₅S
• Molecular Weight: 369.48
• Mol File: 191092-08-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-3-(Tosyloxymethyl)-N-Boc-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(Tosyloxymethyl)-N-Boc-piperidine(191092-08-7)
• EPA Substance Registry System: (R)-3-(Tosyloxymethyl)-N-Boc-piperidine(191092-08-7)

Safety Data

• Hazardous Substances Data: 191092-08-7(Hazardous Substances Data)

Usage

General Description

The chemical (R)-3-(Tosyloxymethyl)-N-Boc-piperidine is a compound with the molecular formula C17H27NO5S. It is a piperidine derivative that is widely used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. The compound is a tosyl-protected Boc-piperidine, meaning that the piperidine nitrogen is masked with a Boc group and the hydroxyl group is protected with a tosyl group. This makes it a versatile intermediate for the synthesis of various biologically active compounds. The compound is also known for its use in the preparation of chiral ligands and catalysts for asymmetric synthesis.

Upstream product

• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 191599-51-6 ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate 
• 37675-18-6 (S)-(+)-nipecotic acid ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 278788-75-3 C₁₅H₂₅N₃O₂ 
• 140645-22-3 (3S)-3-azidomethyl-1-(tert-butoxycarbonyl)-piperidine 
• 140645-23-4 1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate 

Relevant articles and documents

BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY

Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF

The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.