14091-10-2

Basic information

• Product Name: 2-ACETYLAMINO-3-(3,4-DICHLOROPHENYL)ACRYLIC ACID
• Synonyms: 2-ACETYLAMINO-3-(3,4-DICHLOROPHENYL)ACRYLIC ACID
• CAS NO: 14091-10-2
• Molecular Formula: C₁₁H₁₂ClNO₃
• Molecular Weight: 0
• Mol File: 14091-10-2.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-ACETYLAMINO-3-(3,4-DICHLOROPHENYL)ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYLAMINO-3-(3,4-DICHLOROPHENYL)ACRYLIC ACID(14091-10-2)
• EPA Substance Registry System: 2-ACETYLAMINO-3-(3,4-DICHLOROPHENYL)ACRYLIC ACID(14091-10-2)

Safety Data

• Hazardous Substances Data: 14091-10-2(Hazardous Substances Data)

Upstream product

• 106-43-4 para-chlorotoluene 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 4251-65-4 (4-chlorophenyl)acetaldehyde 
• 35175-65-6 acetylamino-(4-chloro-benzyl)-malonic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 93634-55-0 2-methyl-4-(4-chlorobenzylidene)-4H-oxazol-5-one 
• 88681-63-4 2-acetamido-3-(4-chlorophenyl)acrylic acid 
• 875581-67-2 C₁₃H₁₆ClNO₃ 
• 108-24-7 acetic anhydride 
• 88681-63-4 (Z)-2-acetamido-3-(4-chlorophenyl)acrylic acid 
• 14173-39-8 p-chlorophenylalanine 
• 6941-36-2 2-acetylamino-2-(4-chlorobenzyl)malonic acid diethyl ester 
• 7424-00-2 DL-Phe(4Cl) 

Downstream Products

• 14173-39-8 p-chlorophenylalanine 
• 14091-10-2 (S)-2-acetamido-3-(4-chlorophenyl)propanoic acid 
• 1057259-29-6 5-[2-acetylamino-3-(4-chloro-phenyl)-propionylamino]-4-oxo-6-phenyl-2-(2-pyridin-2-yl-ethyl)-hexanoic acid [1-carbamoyl-2-(1H-indol-3-yl)ethyl]-amide 
• 898559-18-7 (S)-ethyl 2-acetamido-3-(4-chlorophenyl)propanoate 
• 129496-71-5 methyl 2-acetylamino-3-(4-chlorophenyl)propanoate 

Relevant articles and documents

Minisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light

A synthetic method that enables the Hantzsch ester-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) under blue LED (light emitting diode) light (456 nm) is described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21–99%. On introducing a chiral phosphoric acid, an asymmetric version of the reaction was also realised and provided product enantiomeric excess (ee) values of 53–99%. The reaction mechanism was delineated to involve excitation of an electron-donor acceptor (EDA) complex, formed from weak electrostatic interactions between the Hantzsch ester and NHPI, which generates the posited radical species of the redox active ester that undergoes addition to the N-heterocycle.

Asymmetric synthesis of unnatural amino acids and tamsulosin chiral intermediate

An efficient and enantioselective hydrogenation of N-acetylamino phenyl acrylic acids was successfully developed by using ruthenium catalyst. This methodology is important in the field of pharmaceuticals and provides a new process for the preparation of unnatural amino acids and tamsulosin chiral intermediate.

Efficient kinetic resolution of amino acids catalyzed by lipase AS 'Amano' via cleavage of an amide bond

Herein the efficient kinetic resolution of non-natural alpha-amino acids catalyzed by lipase AS 'Amano' via cleaving the amide bond is reported. The starting materials were the corresponding amino acid amides and the amino acids were generated with ees of up to 99% with E values of >600. These results indicated that the lipase AS 'Amano' could be a powerful amide hydrolase for the kinetic resolution of amino acid starting from the corresponding amino acid amides.