1416426-76-0Relevant articles and documents
Enantioselective synthesis of functionalized αα-aminophosphonic acid derivatives
Maestro, Aitor,del Corte, Xabier,Martinez de Marigorta, Edorta,Palacios, Francisco,Vicario, Javier
, p. 287 - 291 (2019)
An umpolung process for the enantioselective functionalization of α-aminophosphonates with nucleophiles has been developed. This consists in a formal oxidation of tetrasubstituted α-aminophosphonates to α-iminophosphonates followed by an organocatalyzed nucleophilic addition reaction to the imine bond. The optimal enantioselectivity has been reached by studying the effect of the size of the substituent at the phosphonate. Applications for the preparation of tetrasubstituted α-amino α-cyanophosphonates and α-amino β-nitrophosphonates enantiomerically enriched are reported.
Asymmetric cyanation of a-ketiminophosphonates catalyzed by cinchona alkaloids: Enantioselective synthesis of tetrasubstituted a-aminophosphonic acid derivatives from trisubstituted a-aminophosphonates
Vicario, Javier,Ezpeleta, Jose Mari,Palacios, Francisco
, p. 2641 - 2647 (2013/01/15)
An enantioselective synthesis of tetrasubstituted a-phosphono-a-amino nitriles through asymmetric cyanation of a-ketiminophosphonates catalyzed by Cinchona alkaloids is reported. a-Ket- ACHTUNGTRENUNGiminophosphonates are generated, in a very efficient sy
