141856-12-4Relevant articles and documents
PYRIDO-OXAZINE DERIVATIVES AS ALK5 INHIBITORS
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, (2022/01/24)
The present invention relates to a compound of general formula (I) inhibiting the growth factor receptor transforming β (TGF-β) type I (ALK5), methods for preparing such compounds, pharmaceutical compositions containing them and their therapeutic use. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the ALK5 signaling pathway in a mammal.
Benzodiazepine and Pyridodiazepine Derivatives
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, (2011/12/12)
The present application relates to benzodiazepine and pyridodiazepine derivatives of formula (I) wherein R1, R2, R3, R4, X1, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Synthesis of Lactam and Ketone Precursors of 2,7-Substituted Octahydropyrrolopyrazines and Octahydro-2H-pyridopyrazines
Branden, Stefan Van den,Compernolle, Frans,Hoornaert, Georges J.
, p. 1035 - 1042 (2007/10/02)
This report describes the synthesis of the hexahydropyrrolopyrazin-6(2H)-ones 6, the hexahydropyrrolopyrazin-7(6H)-ones 7, and the hexahydro-2H-pyridopyrazin-7(6H)-ones 8, precursors of 2,7-substituted octahydropyrrolo- and octahydro-