1421-89-2Relevant articles and documents
Bharara et al.
, p. 337,344 (1974)
Amine oxide analogs of certain cholinergic agents.
Cannon,Smith,Fischer
, p. 66 - 68 (1971)
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Sulfur and nitrogen mustard carbonate analogues
Arico, Fabio,Chiurato, Matteo,Peltier, Josephine,Tundo, Pietro
experimental part, p. 3223 - 3228 (2012/07/31)
Sulfur and nitrogen half-mustard compounds lose their aggressive properties when the chlorine atom is replaced by a carbonate moiety. The anchimeric effect of the novel mustard carbonate analogues is investigated. The reaction follows first-order kinetics, does not need any base, and occurs with -OH, -NH and acidic -CH nucleophiles. Most of these molecules are unexplored and might provide a novel strategy for the preparation of compounds previously not easily accessible. Copyright
Synthesis and characterization of photolabile compounds releasing noracetylcholine in the microsecond time range
Peng,Wirz,Goeldner
, p. 398 - 400 (2007/10/03)
The rapid and efficient photochemical release of noracetylcholine 2, an analogue of the neurotransmitter acetylcholine, from its precursor 1 makes this probe well-suited for a dynamic study of the mechanism of hydrolysis of acetylcholine by acetylcholinesterase. The nitrobenzyl derivative 1, the most promising candidate for time-resolved crystallographic studies of this rapid enzyme, displays the required photo-fragmentation kinetics in the microsecond time-range and inhibitory properties oacetylcholinesterase.