14225-79-7

Usage

General Description

1H-Benzimidazole, 2-(2,4-dichlorophenyl)-, also known as omeprazole, is a chemical compound used in the treatment of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid production. It works by inhibiting the proton pump in the stomach lining, reducing the amount of acid produced. Omeprazole is a widely prescribed medication and is available over-the-counter in some countries. It is generally well-tolerated, but may have some side effects such as headache, diarrhea, and nausea. It is important to follow the prescribed dosage and recommendations of a healthcare professional when using this chemical.

InChI:InChI=1/C13H8Cl2N2/c14-8-5-6-9(10(15)7-8)13-16-11-3-1-2-4-12(11)17-13/h1-7H,(H,16,17)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 95-54-5 1,2-diamino-benzene 
• 95-00-1 2,4-dichloro-benzenemethanamine 
• 5330-43-8 N-<(2,4-dichlorophenyl)methylene>benzamine 
• 56843-28-8 2,4-dichlorobenzaldoxime 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 20443-99-6 2,4-dichlorobenzyl bromide 
• 1777-82-8 (2,4-dichlorophenyl)methanol 
• 50-84-0 2,4 dichlorobenzoic acid 

Downstream Products

• 1081111-20-7 2-(2,4-dichlorophenyl)-1-{3-[4-(3-acetylaminophenyl)piperidin-1-yl]propyl}-1H-benzimidazole 

Relevant academic research and scientific papers

Efficient synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles in ball mill without solvent

2-Aryl-1-arylmethyl-1H-benzimidazoles were prepared in excellent yields by the condensation of o-phenylenediamine with aldehydes under mechanically activated solvent-free conditions in ball mill using FeCl3· 6H2O as the catalyst.

4,5-Imidazoledicarboxylic acid immobilized on Fe3O4 magnetic nanoparticles: Preparation, characterization, and application as a recyclable and efficient nanocatalyst in the sonochemical condensation reaction

A green synthesis of benzimidazole derivatives using recyclable magnetic 4,5-imidazoledicarboxylic is described. The magnetic 4,5-imidazoledicarboxylic (Fe3O4@ImDCA) nanocatalyst was characterized completely by infrared spectroscopy

p-Toluenesulfonic acid coated natural phosphate as an efficient catalyst for the synthesis of 2-substituted benzimidazole

2-Substituted benzimidazoles are selectively synthesised in high yields via the condensation of o-phenylenediamine derivatives with aldehyde derivatives using catalytic amount of p-toluenesulfonic acid coated natural phosphate (NP/PTSA) under mild conditions. The use of NP/PTSA as a reusable catalyst makes this process simple, convenient, and environmentally friendly.

A mild and simple one-pot synthesis of 2-substituted benzimidazole derivatives using DDQ as an efficient oxidant at room temperature

A series of 2-substituted benzimidazoles were prepared through one-pot reaction of o-phenylenediamine with various aryl aldehydes in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in acetonitrile as solvent at room temperature. The reacti

Eco-friendly synthesis of 2-substituted benzimidazoles using air as the oxidant

A simple, environmentally friendly procedure for the synthesis of 2-substituted benzimidazoles by the one-pot condensation of o-phenylenediamines with aromatic aldehydes using continuous bubbling of air in absolute ethanol at room temperature is described. The simplicity of the system, mild conditions, involvement of a non-toxic and practically inexhaustible oxidant, easy and quick isolation of the products, and moderate to good yields are the main advantages of this procedure.

Efficient (bromodimethyl)sulfonium bromide mediated synthesis of benzimidazoles

Benzimidazoles have been efficiently synthesized in high yields by treatment of 1,2-phenylenediamine with aldehydes using (bromodimethyl)sulfonium bromide at room temperature.

Improved convenient and environmentally benign synthesis of biological active benzimidazoles using activated carbon and molecular oxygen

The reaction of 1,2-phenylenediamine with a variety of aromatic aldehydes in xylenes gave the corresponding benzimidazole derivatives in good to excellent yields (82-93%) in the presence of dry activated carbon and bubbling molecular oxygen. The present r

Visible-Light Photoredox Catalyzed Double C-H Functionalization: Radical Cascade Cyclization of Ethers with Benzimidazole-Based Cyanamides

A visible-light photoredox catalyzed radical cascade cyclization of simple ethers with cyanamides is developed at room temperature. This strategy involves sequential inert Csp3-H/Csp2-H functionalizations through intermolecular addition reaction of oxyalkyl radicals to N-cyano groups followed by radical cyclization of iminyl radicals in situ generated with C-2 aryl rings. This method allows for efficient synthesis of tetracyclic benzo[4,5]imidazo[1,2-c]quinazolines. Importantly, this is the first example of an intermolecular-intramolecular radical cascade cyclization reaction of cyanamides.

Syntheses, characterization, and catalytic potential of novel vanadium and molybdenum Schiff base complexes for the preparation of benzimidazoles, benzoxazoles, and benzothiazoles under thermal and ultrasonic conditions

A new ONO-tridentate Schiff base ligand (H2L) derived from 3-methoxysalicylaldehyde and nicotinic hydrazide was synthesized and characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, UV–Vis, and powder XRD studies. Then, oxovanadium(V) and dioxomolybdenum(VI) Schiff base complexes, VOL and MoO2L, were also prepared and characterized by different techniques. Moreover, the catalytic activities of both complexes were investigated for the synthesis of benzimidazoles, benzoxazoles, and benzothiazoles under reflux conditions as well as through ultrasonic irradiation. The results revealed several advantages of this procedure, including high product yields, short reaction times, facile work-up procedure, simplicity in operation, eco-friendly reaction conditions, and green aspects by avoiding toxic catalysts and solvents. Graphic abstract: [Figure not available: see fulltext.]

Application of sulfonic acid fabricated cobalt ferrite nanoparticles as effective magnetic nanocatalyst for green and facile synthesis of benzimidazoles

This work represents the design and synthesis of efficient sulfonated cobalt ferrite solid acid catalyst. The synthesized solid acid green catalyst was characterized using various techniques viz. FT-IR, powder XRD, SEM, TEM and VSM. The obtained catalyst was used to synthesize biologically significant 2-substituted benzimidazole derivatives by condensation between o-phenylenediamine with various aromatic, aliphatic and heterocyclic aldehydes. High yield (up to 98 %), short reaction time (10?25 min), mild reaction condition, wide functional group tolerance, easy work-up procedure and excellent values of green chemistry metrices such as lower E factor (0.126), high RME value (88.83 %), carbon efficiency (100 %) and high atom economy (AE) value (90.65 %), are some salient features of the present catalytic system. Moreover, the catalyst recovery by simply using an external magnet and catalyst reusability up to 7 times without any significant loss in catalytic efficiency are some additional remarkable features of the current protocol.