1424-14-2

Basic information

• Product Name: N,N'-DIBENZYLTHIOUREA
• Synonyms: 1,3-Dibenzylthiourea;Dibenzylthiourea;sym-Dibenzylthiourea;Thiourea, bis(phenylmethyl)-;Thiourea, N,N'-bis(phenylmethyl)-;Urea, 1,3-dibenzyl-2-thio-;N,N'-DIBENZYLTHIOUREA;AKOS B029102
• CAS NO: 1424-14-2
• Molecular Formula: C₁₅H₁₆N₂S
• Molecular Weight: 256.37
• EINECS: 215-837-9
• Mol File: 1424-14-2.mol
• Article Data: 53

Chemical Properties

• Melting Point: 146-149°C
• Boiling Point: 405.4°Cat760mmHg
• Flash Point: 199°C
• Appearance: /
• Density: 1.154g/cm³
• BRN: 989212
• CAS DataBase Reference: N,N'-DIBENZYLTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-DIBENZYLTHIOUREA(1424-14-2)
• EPA Substance Registry System: N,N'-DIBENZYLTHIOUREA(1424-14-2)

Safety Data

• Statements: 22
• Safety Statements: 22-36/37
• RIDADR: 2811
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1424-14-2(Hazardous Substances Data)

Usage

Description

N,N'-Dibenzylthiourea, a white crystalline solid with the molecular formula C15H15N3S, is a chemical compound known for its versatile applications. It is primarily recognized as a rubber accelerator and vulcanization agent, playing a crucial role in the production of rubber products. Its unique properties as a sulfur donor enable the crosslinking of polymer chains, thereby enhancing the physical and mechanical properties of the final rubber product. Beyond its industrial applications, N,N'-Dibenzylthiourea has also demonstrated antiviral and antibacterial properties, suggesting its potential use in medical and pharmaceutical fields. However, due to its toxic nature and potential to cause irritation to the skin, eyes, and respiratory system, careful handling is essential.

Uses

Used in Rubber Industry:
N,N'-Dibenzylthiourea is used as a rubber accelerator and vulcanization agent for the production of rubber products. It acts as a sulfur donor to crosslink the polymer chains, improving the physical and mechanical properties of the final rubber product, particularly in the formation of polynorbornene-based rubbers.
Used in Medical and Pharmaceutical Applications:
N,N'-Dibenzylthiourea is used as an antiviral and antibacterial agent due to its demonstrated properties against viruses and bacteria. Its potential use in these applications highlights the compound's versatility beyond the rubber industry, although further research and development are necessary to ensure its safety and efficacy in medical contexts.

Upstream product

• 2944-05-0 carbon monosulfide 
• 100-46-9 benzylamine 
• 32750-91-7 N,N-Diethylcarbaminsaeure-3-semicarbazono-1-phenylbutylester 
• 137-26-8 Thiram 
• 622-78-6 Benzyl isothiocyanate 
• 15867-06-8 N-benzyldithiocarbamic acid 
• 35071-17-1 4-methyl-pyrimidine-2-thione 
• 75-15-0 carbon disulfide 
• 43009-20-7 triethylammonium N-benzyldithiocarbamate 
• 95-53-4 o-toluidine 
• 62-53-3 aniline 
• 14131-62-5 D-glucosamine hydrochloride 
• 419532-33-5 N-phenyl-1,2,3,4,5,7-pentathioazocane 
• 71-36-3 butan-1-ol 

Downstream Products

• 588-46-5 N-(phenylmethyl)acetamide 
• 622-78-6 Benzyl isothiocyanate 
• 15260-36-3 S-methyl-N,N'-dibenzylisothiourea hydroiodide 
• 107457-57-8 S-(2-amino-ethyl)-N,N'-dibenzyl-isothiourea; dihydrobromide 
• 66907-78-6 5-benzylamino-1-benzyltetrazole 
• 6721-03-5 N,N'-methanediylidenebis(1-phenylmethanamine) 
• 63205-37-8 3-benzyl-5-methyl-thiazolidine-2,4-dione 
• 76070-61-6 3-amino-4-benzyl-5-benzylimino-4,5-dihydro-1,2,4-thiadiazole 
• 140-29-4 phenylacetonitrile 
• 900792-97-4 C₃₀H₂₈N₄S₂ 
• 7783-06-4 hydrogen sulfide 
• 100-46-9 benzylamine 
• 76402-06-7 2,4-dibenzyl-3,5-bis(benzylimino)-1,2,4-thiadiazolidine 
• 84384-10-1 1,5-Dibenzyl-3,4,5,6-tetrahydro-4,6-dithioxo-1,3,5-triazin-2(1H)-on 

Relevant articles and documents

A New Synthesis of Aliphatic Isothiocyanates from Primary Amines, Convenient for In Situ Use

Primary aliphatic amines react with carbon disulfide in the presence of BOP (benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate) 1, giving the corresponding isothiocyanates in good to high yields and high purity; a number of isothiocyanates are synthesized and isolated or generated in situ and treated with a nucleophile.

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Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines

A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguandines.

Direct, Microwave-Assisted Synthesis of Isothiocyanates

A microwave-assisted desulfuration of readily available dithiocarbamates, formed in situ from primary amines, leading to target isothiocyanates has been developed. This efficient protocol provides a rapid, environmentally benign route to aliphatic and aromatic isothiocyanates.