1424-14-2

Usage

Uses

Used in Rubber Industry:
N,N'-Dibenzylthiourea is used as a rubber accelerator and vulcanization agent for the production of rubber products. It acts as a sulfur donor to crosslink the polymer chains, improving the physical and mechanical properties of the final rubber product, particularly in the formation of polynorbornene-based rubbers.
Used in Medical and Pharmaceutical Applications:
N,N'-Dibenzylthiourea is used as an antiviral and antibacterial agent due to its demonstrated properties against viruses and bacteria. Its potential use in these applications highlights the compound's versatility beyond the rubber industry, although further research and development are necessary to ensure its safety and efficacy in medical contexts.

Upstream product

• 6630-99-5 1,2,3,4-thiatriazole-5-amine 
• 100-46-9 benzylamine 
• 35071-17-1 4-methyl-pyrimidine-2-thione 
• 622-78-6 Benzyl isothiocyanate 
• 75-15-0 carbon disulfide 
• 463-71-8 thiophosgene 
• 621-83-0 N-benzylthiourea 
• 1748-15-8 1,3-dithiane-2-thione 
• 2382-96-9 benzo[d]oxazole-2-(3H)-thione 
• 56-23-5 tetrachloromethane 
• 32750-91-7 N,N-Diethylcarbaminsaeure-3-semicarbazono-1-phenylbutylester 
• 137-26-8 Thiram 
• 97-74-5 bis(dimethylthiocarbamoyl)sulfide 
• 17356-08-0 thiourea 

Downstream Products

• 588-46-5 N-(phenylmethyl)acetamide 
• 622-78-6 Benzyl isothiocyanate 
• 107457-57-8 S-(2-amino-ethyl)-N,N'-dibenzyl-isothiourea; dihydrobromide 
• 66907-78-6 5-benzylamino-1-benzyltetrazole 
• 6721-03-5 N,N'-methanediylidenebis(1-phenylmethanamine) 
• 7675-39-0 (3-benzyl-2-benzylimino-4-oxo-thiazolidin-5-yl)-acetic acid 
• 63205-37-8 3-benzyl-5-methyl-thiazolidine-2,4-dione 
• 87154-38-9 S-methyl-N,N'-dibenzylisothiourea 
• 76070-61-6 3-amino-4-benzyl-5-benzylimino-4,5-dihydro-1,2,4-thiadiazole 
• 110458-07-6 1,3-dibenzyl-5,5-dimethyl-4,6-dioxohexahydropyrymidine-2-thione 
• 75692-30-7 1,3-dibenzyl-4,5-diisopropylimidazoline-2-thione 
• 85464-44-4 3-Benzyl-2-[(Z)-benzylimino]-4-chloro-thiazolidin-5-one 
• 76070-72-9 C₁₆H₁₈N₄S*2ClH 
• 84384-10-1 1,5-Dibenzyl-3,4,5,6-tetrahydro-4,6-dithioxo-1,3,5-triazin-2(1H)-on 

Relevant academic research and scientific papers

A New Synthesis of Aliphatic Isothiocyanates from Primary Amines, Convenient for In Situ Use

Primary aliphatic amines react with carbon disulfide in the presence of BOP (benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate) 1, giving the corresponding isothiocyanates in good to high yields and high purity; a number of isothiocyanates are synthesized and isolated or generated in situ and treated with a nucleophile.

Identification of organophosphorus simulants for the development of next-generation detection technologies

Organophosphorus (OP) chemical warfare agents (CWAs) represent an ongoing threat but the understandable widespread prohibition of their use places limitations on the development of technologies to counter the effects of any OP CWA release. Herein, we describe new, accessible methods for the identification of appropriate molecular simulants to mimic the hydrogen bond accepting capacity of the PO moiety, common to every member of this class of CWAs. Using the predictive methodologies developed herein, we have identified OP CWA hydrogen bond acceptor simulants for soman and sarin. It is hoped that the effective use of these physical property specific simulants will aid future countermeasure developments.

Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines

A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguandines.

Synthesis Of di- and tri-substituted thiourea derivatives in water using choline chloride–urea catalyst

In this work, di- and tri-substituted thiourea derivatives have been synthesized via a one-pot, three-component reaction from carbon disulfide and aliphatic or aromatic amines using choline chloride-urea deep eutectic solvent as a catalyst in water. Both cyclic and acyclic thiourea derivatives with two or three substituents were synthesized successfully. The reactions were done at 25–100°C, using 5–20 mol% catalyst, in 3–5 h and the GC-Mass yields were between 60% and 95%. All products were characterized using FT-IR, 1H-NMR, 13C-NMR, GC-MS and melting point analyses. The results showed that both water and the DES have important effects on the yield and the rate of this reaction and both of them are necessary to obtain higher yields in less time. The extra experiment, which was designed to study the mechanism of the reaction, showed that an isothiocyanate intermediate was formed in the reaction. Finally, the results showed that by the increase of the amine's nucleophilicity, the reaction occurs faster and gives higher yield.

Pos [...] 4 group metal olefin polymerization catalyst

Embodiments are directed to phosphaguanidine metal complexes of formula I and using those complexes in α-olefin polymerization systems.

Direct, Microwave-Assisted Synthesis of Isothiocyanates

A microwave-assisted desulfuration of readily available dithiocarbamates, formed in situ from primary amines, leading to target isothiocyanates has been developed. This efficient protocol provides a rapid, environmentally benign route to aliphatic and aromatic isothiocyanates.

Rapid and highly efficient synthesis of thioureas in biocompatible basic choline hydroxide

A straightforward and convenient synthesis of symmetrical thiourea derivatives by the reaction of primary amines and carbon disulfide in biocompatible basic choline hydroxide is presented. A variety of biologically important thiourea derivatives can be obtained in good to excellent yields without a tedious work-up under mild reaction conditions. A series of primary aliphatic and aromatic amines with different substituted functional groups have been converted to thiourea derivatives under milder reaction conditions and short reaction times.

Novel self-condensation of ammonium dithiocarbamates leading to symmetrical substituted thioureas

For the first time, the formation of symmetrical substituted thiourea analogues generated by the selfcondensation of trialkylammoniumdithiocarbamates is reported. The reactions occurred under mild conditions. The method allows the use of amines possessing a weak nucleophilic feature in good yields. The highlight of the study is a novel self-condensation mechanism based on dithiocarbamates as a basic compound in organic chemistry.

Green process development for the synthesis of aliphatic symmetrical N,N'-disubstituted thiourea derivatives in aqueous medium

A highly efficient green process for the synthesis of N,N'-disubstituted aliphatic thiourea derivatives using primary aliphatic amines and carbon disulfide in aqueous medium at room temperature via a nonisothiocyanate route is described. This protocol illustrates the rapid preparation of N,N'-disubstituted aliphatic thiourea derivatives in excellent yields with some advantages such as no catalyst and simple workup without any side product formation. Moreover the new route is concise, chromatography-free, and adaptable to pilot-scale preparation.

Green Process Development for the Synthesis of Aliphatic Symmetrical N,N ′-Disubstituted Thiourea Derivatives in Aqueous Medium

A highly efficient green process for the synthesis of N,N′-disubstituted aliphatic thiourea derivatives using primary aliphatic amines and carbon disulfide in an aqueous medium at room temperature via a nonisothiocyanate route is described. This protocol illustrates the rapid preparation of N,N′-disubstituted aliphatic thiourea derivatives in excellent yields with some advantages such as no catalyst and simple workup without any side product formation. Moreover, the new route is concise, does not require chromatography, and is adaptable to pilot-scale preparation. GRAPHICAL ABSTRACT.