142404-84-0

Basic information

• Product Name: 2-ACETYLAMINO-5-BROMO-6-METHYLPYRIDINE
• Synonyms: 2-Acetamido-5-Bromo-6-Picoline;2-Acetamido-5-bromo-6-methylpyridine 98%;2-Acetamido-5-bromo-6-picoline, 2-(Acetylamino)-5-bromo-6-methylpyridine;N-(5-Bromo-6-methylpyridin-2-yl)acetamide;6-Acetamido-3-bromo-ALPHA-picoline;2-Acetamido-5-bromo-6-methylpyridine;2-Acetylamino-5-bromo-6-methylpyridine ,97%;Acetamide, N-(5-bromo-6-methyl-2-pyridinyl)-
• CAS NO: 142404-84-0
• Molecular Formula: C₈H₉BrN₂O
• Molecular Weight: 229.07386
• Product Categories: blocks;Bromides;Pyridines;Pyridine
• Mol File: 142404-84-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 154-158 °C(lit.)
• Boiling Point: 352.8 °C at 760 mmHg
• Flash Point: 167.2 °C
• Appearance: /
• Density: 1.545 g/cm³
• Vapor Pressure: 3.74E-05mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-ACETYLAMINO-5-BROMO-6-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYLAMINO-5-BROMO-6-METHYLPYRIDINE(142404-84-0)
• EPA Substance Registry System: 2-ACETYLAMINO-5-BROMO-6-METHYLPYRIDINE(142404-84-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-42/43
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 142404-84-0(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H9BrN2O/c1-5-7(9)3-4-8(10-5)11-6(2)12/h3-4H,1-2H3,(H,10,11,12)

Upstream product

• 5327-33-3 2-acetylamino-6-methylpyridine 
• 127-09-3 sodium acetate 
• 42753-71-9 5-bromo-6-methyl-pyridin-2-ylamine 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 904326-87-0 N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide 
• 882430-69-5 6-acetamido-3-bromopicolinic acid 

Relevant articles and documents

ADAMANTYL DERIVATES AS P2X7 RECEPTOR ANTAGONISTS

The invention provides compounds of formula (I) pharmaceutically acceptable salt or solvate thereof, in which R1, A1, m and A are as defined in the specification; a process for their preparation; pharmaceutical compositions containin

2-Ethoxy-3-pyridylboronic acid: A versatile reagent for the synthesis of highly-functionalised 3-aryl/heteroaryl-pyridines via Suzuki cross-coupling reactions

This paper describes the commercially-viable synthesis and isolation of 2-ethoxy-3-pyridylboronic acid on a ca. 70 g scale via a directed ortho-metalation reaction on readily-available 2-ethoxypyridine. A range of efficient cross-coupling reactions of 2-ethoxy-3-pyridylboronic acid with selected aryl/heteroaryl halides under palladium-catalysed Suzuki-Miyaura conditions yield novel 2-ethoxy-3-aryl/heteroaryl-pyridines in high yield (heteroaryl=pyridyl, pyrimidyl, pyrazyl). The X-ray crystal structure of 2-ethoxy-3-pyridylboronic acid reveals that the boronic acid group takes part in an intramolecular O-H?O bond with the adjacent ethoxy substituent, and an intermolecular O-H?N bond.

N-bromosuccinimide reactions of some heterocycles in the presence or absence of water: An overview of ring versus side chain bromination for the synthesis of important brominated heterocyclic synthons

Reactions of various heterocycles 1-6 with N-bromosuccinimide in the presence or absence of water have been studied for side chain versus ring bromination to afford some new and important heterocyclic synthons. Interestingly, the N-bromosuccinimide reaction in the presence of perchloric acid, a new condition, affords exclusively the new dibromo aminopicoline 1f, which is not obtained by other presently studied methods.