14246-15-2Relevant articles and documents
Biocatalytic Oxidative Cascade for the Conversion of Fatty Acids into α-Ketoacids via Internal H2O2 Recycling
Gandomkar, Somayyeh,Dennig, Alexander,Dordic, Andela,Hammerer, Lucas,Pickl, Mathias,Haas, Thomas,Hall, Mélanie,Faber, Kurt
supporting information, p. 427 - 430 (2018/02/21)
The functionalization of bio-based chemicals is essential to allow valorization of natural carbon sources. An atom-efficient biocatalytic oxidative cascade was developed for the conversion of saturated fatty acids to α-ketoacids. Employment of P450 monooxygenase in the peroxygenase mode for regioselective α-hydroxylation of fatty acids combined with enantioselective oxidation by α-hydroxyacid oxidase(s) resulted in internal recycling of the oxidant H2O2, thus minimizing degradation of ketoacid product and maximizing biocatalyst lifetime. The O2-dependent cascade relies on catalytic amounts of H2O2 and releases water as sole by-product. Octanoic acid was converted under mild conditions in aqueous buffer to 2-oxooctanoic acid in a simultaneous one-pot two-step cascade in up to >99 % conversion without accumulation of hydroxyacid intermediate. Scale-up allowed isolation of final product in 91 % yield and the cascade was applied to fatty acids of various chain lengths (C6:0 to C10:0).
PROTECTION OF ALCOHOLS AND ACIDS WITH ALLYLSILANES CATALYZED BY IODINE OR IODOTRIMETHYLSILANE IN CHLORINATED HYDROCARBON
Hosomi, Akira,Sakurai, Hideki
, p. 85 - 88 (2007/10/02)
Many triorganosilyl ethers and esters were prepared by the reaction of allylsilanes with alcohols catalyzed by iodine or iodotrimethylsilane in excellent yields.Bromine and bromotrimethylsilane were also effective catalysts.
