1426679-83-5Relevant articles and documents
The mukaiyama type aldol reaction for the synthesis of: Trans-2,6-disubstituted tetrahydropyrans: Synthesis of diospongin a and b
Bharath, Yada,Choudhury, Utkal Mani,Sadhana,Mohapatra, Debendra K.
, p. 9169 - 9181 (2019/11/05)
An efficient synthesis protocol for the preparation of trans-2,6-disubstituted tetrahydropyrans by the reaction of 1-phenyl-1-triemthylsiloxyethylene with six membered cyclic hemiacetals in the presence of iodine is developed. This reaction proceeds smoothly under mild conditions employing a catalytic amount of molecular iodine. The feature of this novel conversion includes milder reaction conditions, broader substrate scope, functional group tolerance and good diastereoselectivity. The efficiency and practicality of the current method were successfully displayed in the total synthesis of diospongin A and B in good yields.
A flexible enantioselective synthesis of (+)-centrolobine and 5-epi-diospongin-A using asymmetric transfer hydrogenation/tandem Grubbs cross-metathesis/oxy-Michael reaction as key steps
Kumaraswamy, Gullapalli,Rambabu, Dasa
, p. 196 - 201 (2013/04/10)
An efficient enantioselective synthesis of (+)-centrolobine and 5-epi-diospongin-A was achieved by the use of asymmetric transfer hydrogenation (ATH)/tandem Grubbs cross-metathesis/oxy-Michael reaction. Furthermore, this strategy allows for diastereodiver
