142819-61-2

Upstream product

• 4706-43-8 1-benzyl-1H-benzotriazole 
• 538-51-2 benzylidene phenylamine 
• 142819-59-8 2-anilino-1-(benzotriazol-1-yl)-1,2-diphenylethane 
• 95-14-7 1,2,3-Benzotriazole 
• 501-65-5 diphenyl acetylene 
• 142321-29-7 1-(hex-1-en-2-yl)-1H-benzo[d][1,2,3]triazole 
• 23269-74-1 1-[1-(phenyl)vinyl]-1H-benzo[d][1,2,3]triazole 
• 100-52-7 benzaldehyde 

Downstream Products

• 1684-14-6 2,3-diphenylquinoxaline 
• 501-65-5 diphenyl acetylene 

Relevant academic research and scientific papers

A novel synthesis of diarylacetylenes from N-arylmethylheteroarenes and N-arylmethyleneanilines

Aromatic enamines and diarylacetylenes may be obtained in a novel one-step synthesis involving the condensation of N-arylmethyl heterocycles with aromatic imines in the presence of a strong base. The enamines are isolable intermediates on the route to diarylacetylenes via the elimination of the nitrogen heterocycle.

Simple and efficient diaryl alkyne synthesis method

The embodiment of the invention discloses a simple and efficient diaryl alkyne synthesis method. The method comprises the steps of by taking arylmethylbenzotriazole and aromatic aldehyde as raw materials, carrying out addition and double-beta-elimination reaction under the action of bis (trimethylsilyl) amino salt MN (SiMe3) 2 to synthesize diaryl alkyne by a one-pot method. The raw materials and chemical reagents used in the method are easy to obtain, the reaction conditions are mild, the operation is simple, the substrate universality is good, the product yield is high, and the method is a simple and efficient diaryl alkyne synthesis method.

Ambient benzotriazole ring opening through intermolecular radical addition to vinyltriazole

Radical addition to vinyltriazole was developed as a new approach to achieve 1,2,3-triazole ring opening under mild conditions. Through reagent control, excellent chemoselectivity was achieved, giving either nitrile under basic conditions or quinoxaline under neutral conditions. Reactivities made this method an attractive new reaction mode.

New Synthesis of Diarylalkynes from 1-(Arylmethyl)benzotriazoles and Arylideneamines

The Michael addition of lithio derivatives 2 of 1-(arylmethyl)benzotriazoles 1 to arylideneamines 3-5 gave the corresponding 1-(benzotriazol-1-yl)-2-anilino (or tosylamino)-1,2-diarylethanes 6-8.The latter were shown to undergo a double elimination reaction under the action of ButOK in DMF to afford diarylalkynes in high yields.