4706-43-8Relevant articles and documents
Scalable Synthesis of Benzotriazoles via [3+2] Cycloaddition of Azides and Arynes in Flow
Kleoff, Merlin,Boeser, Lisa,Baranyi, Linda,Heretsch, Philipp
supporting information, p. 979 - 982 (2021/01/18)
A method for the metal-free synthesis of benzotriazoles in flow is reported. Using azides and in situ generated arynes, benzotriazoles are formed in a [3+2] cycloaddition within minutes. Employing different substitution patterns of the azide and aryne coupling partners, a modular access to benzotriazoles is provided. Thermal strain of hazardous azides and accumulation of reactive intermediates is minimized by short reaction times in flow, improving the safety profile of the process. The scalability of the reaction is demonstrated.
Synthesis, characterization, and antimicrobial activity of lipophilic N,N′-bis-substituted triazolium salts
Fico, Dominic,Gorden, John D.,Johnson, Shanina S.,King, Lauren B.,Lin, Zi Jie,Martz, Luke,Rodriguez, Isabelle,Shelton, Kerri L.,Ta, Thong,Wilson, Julie A.
supporting information, (2021/11/30)
A series of N,N′-bis-substituted triazolium salts have been synthesized using 1H-1,2,4-triazole, 1H-1,2,3-triazole, and 1H-1,2,3-benzotriazole. Synthesized compounds were tested for their antimicrobial activities against a panel of representative ESKAPE p
A convenient way for alkylation of amines using xanthate esters
Sukrutha, Kodipura P.,Swaroop, Toreshettahally R.,Preetham, Ramesh,Lokanath, Neratur K.,Rangappa, Kanchugarakoppal S.,Sadashiva, Maralinganadoddi P.
, p. 2316 - 2323 (2021/06/14)
N-alkylation of amines by the reaction with xanthate esters in the presence of acetic acid catalyst in ethanol is reported. Short reaction time, high yield, general applicability and environmentally benign nature are the noteworthy features of our protocol. The probable mechanism for the formation N-alkylation of amines is proposed.