New methods for the synthesis of 3'-S-phosphorothiolate internucleoside linkages

DOI: 10.1016/S0040-4039(00)79587-6

Source and publish data:

Tetrahedron Letters p. 3017 - 3020 (1992)

Update date:2022-09-26

Topics:

Authors:

Vyle Vyle

Cosstick

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Article abstract of DOI:10.1016/S0040-4039(00)79587-6

Efficient procedures are described for the synthesis of dinucleoside phosphorothiolates using either a Michaelis-Arbusov-type reaction or a phosphotriester approach.

Full text of DOI:10.1016/S0040-4039(00)79587-6

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Product name:3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine

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