14292-27-4Relevant articles and documents
Method for producing aliphatic carboxylic acid compound and pyridine compound adduct of aliphatic ketone compound
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Paragraph 0172; 0175-0176; 0182; 0185-0186; 0192; 0195-0196, (2020/05/02)
Provided are: a method for producing an aliphatic carboxylic acid compound safely and easily from a starting material that can be obtained or produced industrially without generating a harmful substance such as haloform; and a pyridine compound adduct of an aliphatic ketone compound. The method for producing an aliphatic carboxylic acid compound is a method for producing an aliphatic carboxylic acid compound represented by Formula (I), and comprises: a first step for obtaining a pyridine compound adduct by adding a pyridine compound to an aliphatic ketone compound having an alpha-methyl groupin the presence of an oxidizing agent; and a second step of hydrolyzing the pyridine compound adduct in the presence of a base. In the Formula, R1 represents a substituted or unsubstituted linear alkyl group having 4-8 carbon atoms or a substituted or unsubstituted branched alkyl group having 4-8 carbon atoms; M represents hydrogen, a metal belonging to Group 1 or Group 2 of the periodic table, amethyl group, an ethyl group, an n-propyl group or an isopropyl group.
The synthesis of medium-chain-length β-hydroxy esters via the reformatsky reaction
Sailer, Miloslav,Dubicki, Krystyn I.,Sorensen, John L.
, p. 79 - 82 (2015/02/02)
The synthesis of medium-chain-length β-hydroxy esters in good yield via the Reformatsky reaction is described. This work will be used as the basis for further investigation of hydroxyalkanoate polymers as potential feedstock for biofuel production.
Formation of an enolate intermediate is required for the reaction catalyzed by 3-hydroxyacyl-CoA dehydrogenase
Liu, Xiaojun,Deng, Guisheng,Chu, Xiusheng,Li, Nan,Wu, Long,Li, Ding
, p. 3187 - 3190 (2008/02/05)
Fluorinated substrate analogs were synthesized and incubated with rat liver 3-hydroxyacyl-CoA dehydrogenase, which reveals that the formation of an enolate intermediate is required for the reaction catalyzed by the enzyme.