14292-85-4Relevant articles and documents
Synthesis of Unprotected and Highly Substituted Indoles by the Ruthenium(II)-Catalyzed Reaction of Phenyl Isocyanates with Diaryl/Diheteroaryl Alkynes/Ethyl-3-phenyl Propiolates
Kumar, Amrendra,Tadigoppula, Narender
supporting information, p. 8 - 12 (2021/01/13)
A one-pot transformation has been developed for the synthesis of unprotected and highly substituted indoles by an in situ installed carbamide-directed Ru(II)-catalyzed intermolecular oxidative annulation of phenyl isocyanates with diaryl/diheteroaryl alkynes/ethyl phenyl propiolates in the presence of Cu(OAc)2·H2O as an oxidant and AgSbF6 as an additive at 120 °C within 3 h.
A general synthesis of arylindoles and (1-arylvinyl)carbazoles: Via a one-pot reaction from N -tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer
Bzeih, Tourin,Naret, Timothée,Hachem, Ali,Jaber, Nada,Khalaf, Ali,Bignon, Jerome,Brion, Jean-Daniel,Alami, Mouad,Hamze, Abdallah
, p. 13027 - 13030 (2016/11/09)
A convergent and effective synthesis of 3-aryl-indoles, 2,3-diaryl indoles, and (1-arylvinyl)carbazoles from a one-pot sequence involving the coupling of N-tosylhydrazones with ortho-nitro-haloarenes followed by a cyclization has been developed. Compound 5i exhibits excellent antiproliferative activity in the low nM range against colon cancer cell lines.
Synthesis of indoles via palladium-catalyzed C-H activation of N-aryl amides followed by coupling with alkynes
Zhou, Feng,Han, Xiuling,Lu, Xiyan
supporting information; experimental part, p. 4681 - 4685 (2011/09/30)
A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved.