14294-10-1

Basic information

• Product Name: MORPHOLINE-4-CARBOTHIOAMIDE
• Synonyms: 1-MORPHOLINETHIOCARBOXIMIDE;4-MORPHOLINECARBOTHIOAMIDE;Morpholine-4-carbothioamide ,97%;4-(Aminothiocarbonyl)morpholine;4-Thiocarbamoylmorpholine;Morpholine-N-carbothioamide;Morpholinothiourea;N-Morpholinothioamide
• CAS NO: 14294-10-1
• Molecular Formula: C₅H₁₀N₂OS
• Molecular Weight: 146.213
• Mol File: 14294-10-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 176-177℃
• Boiling Point: 259℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.273
• Vapor Pressure: 0.0131mmHg at 25°C
• Refractive Index: 1.594
• PKA: 16.13±0.20(Predicted)
• CAS DataBase Reference: MORPHOLINE-4-CARBOTHIOAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLINE-4-CARBOTHIOAMIDE(14294-10-1)
• EPA Substance Registry System: MORPHOLINE-4-CARBOTHIOAMIDE(14294-10-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39
• RIDADR: 2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 14294-10-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

InChI:InChI=1/C5H10N2OS/c6-5(9)7-1-3-8-4-2-7/h1-4H2,(H2,6,9)

Upstream product

• 110-91-8 morpholine 
• 625-57-0 O-ethyl thiocarbamate 
• 540-72-7 sodium thiocyanide 
• 109-02-4 4-methyl-morpholine 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 40398-30-9 N-(morpholinothiocarbonyl)benzamide 
• 1094484-89-5 2-mercapto-2-morpholin-4-yl-2,3,5,6,7,8-hexahydro-4H-1,3-benzoxazin-4-one 
• 314278-55-2 benzotriazol-1-yl(tetrahydro-1H-1,4-oxazin-4-yl)methanimine 
• 862873-20-9 4-(1H-imidazol-1-ylcarbonothioyl)morpholine 
• 55113-93-4 morpholine-4-carbothioic acid 1,1-dimethyl-3-oxo-butylamide 
• 288-32-4 1H-imidazole 
• 75-15-0 carbon disulfide 
• 1530-89-8 N-cyanomorpholine 

Downstream Products

• 19983-28-9 (4-(4-phenylthiazol-2-yl)morpholine) 
• 1195768-94-5 3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline 
• 1195767-56-6 N-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(4-morpholinyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}methyl)cyclopentanecarboxamide 
• 1195767-57-7 N-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(4-morpholinyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}methyl)-2-methylpropanamide 
• 1195767-55-5 2,5-difluoro-N-{2-fluoro-3-[5-(2-{[(methylsulfonyl)amino]methyl}-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide 
• 1195769-49-3 N-{3-[5-[2-(aminomethyl)-4-pyrimidinyl]-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide 
• 1195769-48-2 N-{3-[5-(2-cyano-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide 
• 1195768-35-4 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide 
• 1195768-36-5 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide 
• 1195768-96-7 N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}cyclohexanesulfonamide 
• 1195765-30-0 N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}cyclohexanesulfonamide 

Relevant articles and documents

Pyrrole-thiazole based push-pull chromophores: An experimental and theoretical approach to structural, spectroscopic and NLO properties of the novel styryl dyes

Novel push-pull fluorophores constituted by two donors (substituted pyrrole and morpholine) linked to acceptor through thiazole electron spacer have been synthesized. The fluorophores are investigated for linear and non-linear optical properties by UV-VIS absorption and fluorescence spectroscopies, and by means of TD-DFT (B3LYP/6-31G(d)) method, with the aim of elucidating the ability of the morpholine/pyrrole-donor-thiazole-spacer based D-π-A fluorophores as organic NLO materials. The bond length alternation and generalized Mulliken-Hush (GMH) analysis is performed to understand the involvement of the donor in effective transfer of the charge to acceptor. Values of first-order hyperpolarizabilities (βCT or β0), obtained by the solvatochromic method (Lippert Mataga model), and the transition dipole moments (μeg) used to characterize and evaluate the non-linear optical performances of the D-π-A fluorophores in various microenvironments. The D-π-A fluorophores possess good values of βCT or β0 in different organic solvents and hold high thermal stabilities therefore can be used as potential organic NLO materials.

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Imidazo ring PAR4 antagonist and medical applications thereof

The invention relates to an imidazo ring compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt or ester or solvate thereof. The compound disclosed by the inventioncan be used for preparing medicines for preventing or treating thromboembolic diseases.