142980-15-2Relevant academic research and scientific papers
C-linked galactosyl serine AFGP analogues as potent recrystallization inhibitors
Liu, Suhuai,Ben, Robert N.
, p. 2385 - 2388 (2007/10/03)
(Chemical Equation Presented) A series of C-linked antifreeze glycoprotein analogues have been prepared to evaluate antifreeze activity as a function of distance between the carbohydrate moiety and polypeptide backbone. The building blocks for these analogues were prepared using either an olefin cross-metathesis or catalytic asymmetric hydrogenation. Analysis of antifreeze protein-specific activity revealed that only analogue 2a (n = 1) was a potent recrystallization inhibitor and thus has potential medical and industrial applications.
