142997-96-4

Upstream product

• 263011-57-0 (2S,3R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-oxirane-2-carbaldehyde 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 
• 81520-05-0 [(2R,3R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-oxiranyl]-methanol 

Downstream Products

• 69056-12-8 (+)-Prelog-Djerassi lactonic acid 
• 144606-47-3 (2R,4S,5S,6S)-7-benzyloxy-5-hydroxy-2,4,6-trimethylheptanoic acid δ-lactone 

Relevant academic research and scientific papers

Synthesis of the Prelog-Djerassi Lactone and Protomycinolide IV Based on the Stereospecific Methylation of γ,δ-Epoxy Acrylates by Trimethylaluminum

The Prelog-Djerassi lactone, a key intermediate for the synthesis of several medicinally important macrolide antibiotics, and protomycinolide IV, a 16-membered macrolide, have been synthesized by employing the recently developed stereospecific methylation of γ,δ-epoxy acrylates by trimethylaluminum as key steps.