Synthesis of the Prelog-Djerassi Lactone and Protomycinolide IV Based on the Stereospecific Methylation of γ,δ-Epoxy Acrylates by Trimethylaluminum

DOI: 10.1246/cl.1992.1101

Source and publish data:

Chemistry Letters p. 1101 - 1104 (1992)

Update date:2022-08-02

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Authors:

Miyashita, Masaaki

Hoshino, Masahide

Yoshikoshi, Akira

Kawamine, Katsumi

Yoshihara, Kousei

Irie, Hiroshi

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Article abstract of DOI:10.1246/cl.1992.1101

The Prelog-Djerassi lactone, a key intermediate for the synthesis of several medicinally important macrolide antibiotics, and protomycinolide IV, a 16-membered macrolide, have been synthesized by employing the recently developed stereospecific methylation of γ,δ-epoxy acrylates by trimethylaluminum as key steps.

Full text of DOI:10.1246/cl.1992.1101

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