143-74-8 Usage
Chemical Properties
dark red powder
Uses
Different sources of media describe the Uses of 143-74-8 differently. You can refer to the following data:
1. As indicator in 0.02-0.05% alcohol solution. pH 6.8 yellow, 8.4 red.
2. Phenol red is used as a non absorbed marker in gravimetric method. It is a pH indicator used in cell biology laboratories and in home swimming pool test kits. It is used to check the kidney function based on the excreted phenol red by colorimetric method.
Definition
ChEBI: 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an
indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney.
Biochem/physiol Actions
Phenol Red is a pH indicator which changes color from yellow to red.
Safety Profile
Moderately toxic by ingestion and intravenous routes. Mutation data reported. When heated to decomposition it emits toxicvapors of SOx.
Enzyme inhibitor
This pH-indicating dye (FW = 354.38 g/mol; CAS 143-74-8; pKa = 7.9; yellow < pH 6.8; red > pH 8.4), also known as phenolsulfonphthalein and sulfophthalein, is a diagnostic aid for evaluating renal function. A typical stock indicator solution is 0.1 g phenol red in 28.2 mL 10 mM NaOH and 221.8 mL water. Target(s): aldehyde reductase; glutaminase; gglutamyl transpeptidase; glutathione S-transferase; 4- methyleneglutaminase; phosphate uptake; thromboxane A2/prostaglandin H2 receptor; and thyroglobulin iodination.
Check Digit Verification of cas no
The CAS Registry Mumber 143-74-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 143-74:
(5*1)+(4*4)+(3*3)+(2*7)+(1*4)=48
48 % 10 = 8
So 143-74-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H14O5S/c20-15-9-5-13(6-10-15)19(14-7-11-16(21)12-8-14)17-3-1-2-4-18(17)25(22,23)24-19/h1-12,20-21H
143-74-8Relevant articles and documents
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Orndorff,Sherwood
, p. 486 (1923)
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Solvent-free synthesis of sulfonephthaleins, sulfonefluoresceins and fluoresceins under microwave irradiation
Cihelnik, Simon,Stibor, Ivan,Lhotak, Pavel
, p. 1779 - 1789 (2007/10/03)
An efficient solvent-free synthesis of sulfonephthaleins, sulfonefluoresceins and fluoresceins under microwave irradiation is reported.