143264-73-7

Upstream product

• 67-56-1 methanol 
• 143264-72-6 N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-hydroxypyrrolidine 
• 132974-83-5 (5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one 
• 132974-84-6 (-)-(5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-tosylpyrrolidin-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 17342-08-4 (S)-Pyroglutaminol 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 143264-79-3 (2R,5R)-2-Methoxy-1-(toluene-4-sulfonyl)-5-((E)-5-trimethylsilanyl-pent-4-enyl)-pyrrolidine 
• 143264-76-0 (E)-6-[(2R,5R)-5-Methoxy-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-hex-3-en-2-one 
• 143264-77-1 (-)-N-tosylanatoxin-a 
• 143264-78-2 4-[(2R,5R)-5-Methoxy-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-butan-1-ol 
• 143264-80-6 (1R,6R)-9-(Toluene-4-sulfonyl)-2-vinyl-9-aza-bicyclo[4.2.1]nonane 
• 143264-75-9 (2R,5R)-2-But-3-enyl-5-methoxy-1-(toluene-4-sulfonyl)-pyrrolidine 
• 64285-06-9 anatoxin-a 
• 143264-74-8 [(2S,5R)-5-Methoxy-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanol 

Relevant academic research and scientific papers

The synthesis of 4'-t-butylcarbamyl- and 4'-p-toluenesulphonamidyl-2',3'- dideoxy pyrimidine nucleoside analogues

The preparation of 4'-t-butylcarbamyl-2',3'-dideoxy thymidine, uridine and 5-ethyl uridine nucleoside analogues and 4'-p-toluenesulphonamidyl-2',3'- dideoxy thymidine and 5-ethyl uridine nucleoside analogues from L- pyroglutamic acid is reported.

A short and enantioselective synthesis of (+)-Anatoxin-a

A short and enantioselective total synthesis of the neurotoxic alkaloid (+)-Anatoxin-a (1) from the L-pyroglutamic acid derivative 2 is described. The key step involves an intramolecular cyclisation of an N-tosyl iminium ion derived from the corresponding α-methoxy sulfonamide.