143285-53-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 131550-34-0 (S)-2-Cyclohexyl-1-((4R,5S)-5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine 
• 189996-60-9 2,3-O-isopropylidene-D-erythrose 
• 147879-36-5 (3R,4S)-3,4-Dihydroxy-6-methylhept-1-ene 
• 147879-37-6 (2S,3S)-2,3-dihydroxy-5-methyl-4-hexenoic acid acetonide 
• 950182-24-8 (3aR,6R,6aR)-2,2-dimethyl-6-(tosyloxymethyl)-tetrahydro-2H-furo[3,4-d]-1,3-dioxol-4-ol 
• 143285-43-2 (R)-2-Cyclohexyl-1-[(4R,5S)-2,2-dimethyl-5-(2-methyl-propenyl)-[1,3]dioxolan-4-yl]-ethanol 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 147879-39-8 (3S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methyl-5-hepten-2-one acetonide 
• 147879-38-7 methyl (2S,3S)-2,3-dihydroxy-5-methyl-4-hexenoate acetonide 
• 139727-17-6 (4S,5R)-2,2-Dimethyl-4-(2-methylpropan-1-yl)-5-vinyl-1,3-dioxolane 
• 141364-53-6 N'-[(S)-2-Cyclohexyl-1-((4R,5S)-5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-N,N-dimethyl-hydrazine 
• 139727-13-2 (4S,5R)-2,2-Dimethyl-4-(2-methyl-1-propenyl)-5-(hydroxymethyl)-1,3-dioxolane 
• 141364-54-7 (4S,5R)-2,2-Dimethyl-4-(2-methylpropan-1-yl)-5-(hydroxymethyl)-1,3-dioxolane 

Downstream Products

• 104882-10-2 (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 122621-77-6 (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 

Relevant academic research and scientific papers

Dipeptide Isosteres. 1. Synthesis of Dihydroxyethylene Dipeptide Isosteres via Diastereoselective Additions of Alkyllithium Reagents to N,N-Dimethylhydrazones. Preparation of Renin and HIV-1 Protease Inhibitor Transition-State Mimics

The amino and diamino dihydroxyethylene dipeptide isosteres 19a,b and 23 are important intermediates for the preparation of inhibitors of human renin and HIV-1 protease, respectively.A general synthetic strategy was developed to access both dipeptide isos

A VERSATILE AND STEREOSPECIFIC SYNTHESIS OF A DIHYDROXYETHYLENE DIPEPTIDE ISOSTERE OF RENIN INHIBITORS FROM D-RIBOSE

(2S,3R,4S)-2-Amino-1-cyclohexyl-6-methylheptane-3,4-diol, a dihydroxyethylene dipeptide isostere for renin inhibitors, was synthesized from D-ribose stereospecifically.This method can be readily adapted to other dihydroxyethylene isosteres.