1433773-40-0

Basic information

• Product Name: C₁₄H₁₂BrN
• Synonyms: C₁₄H₁₂BrN
• CAS NO: 1433773-40-0
• Molecular Weight: 274.16
• Mol File: 1433773-40-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₂BrN(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₂BrN(1433773-40-0)
• EPA Substance Registry System: C₁₄H₁₂BrN(1433773-40-0)

Safety Data

• Hazardous Substances Data: 1433773-40-0(Hazardous Substances Data)

Upstream product

• 1433772-22-5 N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 583-53-9 2,3-dibromobenzene 
• 551-93-9 2-aminoacetophenone 
• 244205-40-1 (2-bromophenyl)boronic acid 
• 1885-29-6 anthranilic acid nitrile 

Downstream Products

• 611-64-3 9-methyl-acridine 

Relevant articles and documents

Iodine-Promoted Formal [5+1] Annulation of 2-Vinylanilines and Thiurams: A Facile Approach to the Synthesis of 2-Aminoquinolines

Quinolines, especially 2-aminoquinolines, are highly important heterocycles in medicinal chemistry. 2-Aminoquinolines can be synthesized by stepwise construction of the quinoline ring followed by additional amination; however, this protocol is cumbersome. Here, we describe a [5+1]-cyclization of 2-vinylanilines with tetraalkylthiuram disulfides in the presence of iodine and copper(II) triflate. This reaction directly employs readily available and low-cost thiuram as both a C1 synthon and a nitrogen source, providing a facile approach to one-step syntheses of a variety of 2-aminoquinolines in good to excellent yields.