383875-60-3

Usage

Uses

Used in Medicinal Chemistry:
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMois used as a chemical scaffold for the development of new pharmaceuticals, leveraging the pyrrolopyridine class's potential in medicinal applications.
Used in Drug Discovery:
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMoserves as a starting point for drug discovery, where its structure can be modified to explore new therapeutic agents with improved properties and efficacy.
Used in Chemical Modification and Derivatization:
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMois utilized for further chemical modification, allowing researchers to create a variety of derivatives with tailored biological activities and properties.
Used in Synthesis of Novel Molecules:
As a building block, 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMois employed in the synthesis of innovative molecules that may have applications in various therapeutic areas within the pharmaceutical industry.

Upstream product

• 100-97-0 hexamethylenetetramine 
• 108-24-7 acetic anhydride 
• 143468-13-7 6-Bromo-1H-pyrrolo<2,3-b>pyridine 
• 143468-12-6 1-Benzoyl-6-bromo-1H-pyrrolo<2,3-b>pyridine 
• 64-19-7 acetic acid 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 

Downstream Products

• 1471250-25-5 (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(1,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid 

Relevant academic research and scientific papers

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

Azaindole derivatives, process for their preparation, and their use as antitumor agents

Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I): wherein R is a hydrogen or halogen atom or a group selected from —CN, —OH, —OCOR4, —(CH2)nNH2, —(CH2)nNHR4, —(CH2)nNHCOR4, —(CH2)nNHCONR4R5, —(CH2)nNHCOOR4, or —(CH2)nNHSO2R4, wherein n is either 0 or 1, R4and R5are as described in the specification; R1is hydrogen or an optionally substituted alkyl group; R2is an optionally substituted group selected from alkyl or aryl; R3is hydrogen or a group selected from —CONR4R5, —COOR4, —CONHOR4, —SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed. These compounds are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.