14348-40-4

Basic information

• Product Name: 3-Hydroxy-2,4,6-tribromobenzoic acid
• Synonyms: 3-Hydroxy-2,4,6-tribromobenzoic acid >97%;2,4,6-Tribromo-3-hydroxybenzonic acid;2,4,6-Tribromo-3-hydroxybenzoic Acid [for Biochemical Research];2,4,6-Tribromo-3-hydroxybenzoic acid ,99%;2,4,6-Tribromo-3-hyd;3-Hydroxy-2,4,6-tribromobenzoic aicd;2,4,6-TribroMo-3-hydroxybenzoic Acid 2,4,6-TribroMo-3-hydroxybenzoic acid (TBHBA)
• CAS NO: 14348-40-4
• Molecular Formula: C₇H₃Br₃O₃
• Molecular Weight: 374.81
• EINECS: 2017-001-1
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Enzyme substrates;substrate;Pharmaceutical Raw Materials
• Mol File: 14348-40-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 145-148 °C(lit.)
• Boiling Point: 121°C (rough estimate)
• Flash Point: 168.7 °C
• Appearance: White/Crystals
• Density: 2.3705 (rough estimate)
• Vapor Pressure: 1.16E-05mmHg at 25°C
• Refractive Index: 1.5438 (estimate)
• Storage Temp.: Store at RT.
• PKA: 1.15±0.10(Predicted)
• Water Solubility: insoluble
• BRN: 2844497
• CAS DataBase Reference: 3-Hydroxy-2,4,6-tribromobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-2,4,6-tribromobenzoic acid(14348-40-4)
• EPA Substance Registry System: 3-Hydroxy-2,4,6-tribromobenzoic acid(14348-40-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38-20/22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 14348-40-4(Hazardous Substances Data)

Usage

Chemical Properties

White crystals

InChI:InChI=1/C7H3Br3O3/c8-2-1-3(9)6(11)5(10)4(2)7(12)13/h1,11H,(H,12,13)/p-1

Synthetic route

3-Carboxyphenol (99-06-9) → 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4)

Conditions	Yield
With bromine
With bromine; acetic acid
With hydrogen bromide; dihydrogen peroxide
With hydrogenchloride; bromine bromate

3-Carboxyphenol (99-06-9) → 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4) + 2,4-dibromo-5-hydroxybenzoic acid (14348-39-1)

Conditions	Yield
With acetic acid durch Bromierung;

water (7732-18-5) + bromine (7726-95-6) + 3-Carboxyphenol (99-06-9) → 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4)

3-Carboxyphenol (99-06-9) + bromine water (3 mol bromo) → 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4)

hydrogen bromide (10035-10-6, 12258-64-9) + 3-Carboxyphenol (99-06-9) + diluted hydrogen peroxide → 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4)

acetic acid (64-19-7) + 3-Carboxyphenol (99-06-9) + bromine (3 mol ) → 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4) + 2,4-dibromo-5-hydroxybenzoic acid (14348-39-1)

acetic acid (64-19-7) + 3-Carboxyphenol (99-06-9) + bromine (2 mol ) → 4-bromo-3-hydroxybenzoic acid (14348-38-0) + 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4) + 2,4-dibromo-5-hydroxybenzoic acid (14348-39-1)

chloro-trimethyl-silane (75-77-4) + 2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4) → 2,4,6-tribromo-3-trimethylsiloxybenzoic acid trimethylsilyl ester (79302-45-7)

Conditions	Yield
With triethylamine In toluene for 2h; Heating;	89%

2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4) → 2-bromo-3-hydroxy-4,6-dinitro-benzoic acid

Conditions	Yield
With nitric acid

2,4,6-tribromo-3-hydroxy-benzoic acid (14348-40-4) + nitric acid (7697-37-2) → 2-bromo-3-hydroxy-4,6-dinitro-benzoic acid

Upstream product

• 99-06-9 3-Carboxyphenol 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 10035-10-6 hydrogen bromide 
• 64-19-7 acetic acid 

Downstream Products

• 79302-45-7 2,4,6-tribromo-3-trimethylsiloxybenzoic acid trimethylsilyl ester