1435-53-6

Basic information

• Product Name: 2,4-Dibromo-1-fluorobenzene
• Synonyms: Benzene, 2,4-dibromo-1-fluoro-;1,3-DIBROMO-4-FLUOROBENZENE;1-FLUORO-2,4-DIBROMOBENZENE;2,4-DIBROMOFLUOROBENZENE;2,4-DIBROMO-1-FLUOROBENZENE;1,3-Dibromo-4-fluorobenzene, tech., 85%;1,3-Dibromo-4-fluorobenzene 98%;1,3-Dibromo-4-fluorobenzene98%
• CAS NO: 1435-53-6
• Molecular Formula: C₆H₃Br₂F
• Molecular Weight: 253.89
• EINECS: 215-860-4
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Fluorobenzene;Bromine Compounds;Fluorine Compounds;Aryl;C6;Halogenated Hydrocarbons;Fluorine series
• Mol File: 1435-53-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 69°C
• Boiling Point: 105-110 °C (22 mmHg)
• Flash Point: 92 °C
• Appearance: Clear colorless/Liquid
• Density: 2.047 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00261mmHg at 25°C
• Refractive Index: 1.582-1.584
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: insoluble
• BRN: 1934822
• CAS DataBase Reference: 2,4-Dibromo-1-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dibromo-1-fluorobenzene(1435-53-6)
• EPA Substance Registry System: 2,4-Dibromo-1-fluorobenzene(1435-53-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1435-53-6(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C7H4F3NO2S/c8-7(9,10)4-1-2-6(14)5(3-4)11(12)13/h1-3,14H

Upstream product

• 462-06-6 fluorobenzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 2924-09-6 5-bromo-2-fluoroaniline 
• 1493-27-2 ortho-nitrofluorobenzene 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 
• 7726-95-6 bromine 

Downstream Products

• 850792-76-6 3-[4-(5-bromo-2-fluoro-phenoxy)-2-methyl-phenyl]propionic acid methyl ester 
• 850792-74-4 3-[4-(3-bromo-4-fluoro-phenoxy)-2-methyl-phenyl]propionic acid methyl ester 
• 1065607-12-6 3-(2,4-dibromophenoxy)pyridin-2-amine 
• 345635-35-0 (2,4-dibromo-phenyl)-methyl sulfide 
• 1147334-61-9 ethyl 3-(3-bromo-4-fluorophenyl)acrylate 
• 1220329-26-9 (3aR,5R,7aS)-5-(benzyloxymethyl)-7a-(5-bromo-2-fluorophenyl)-1,3,3a,4,5,7-hexahydropyrano[3,4-c]isoxazole 
• 1424360-09-7 1,3-di(2-thienyl)-4-fluorobenzene 
• 1424360-05-3 1,3-di(2'-methoxyphenyl)-4-fluorobenzene 
• 425379-21-1 5'-bromo-6,2'-difluorobiphenyl-2-carbonitrile 

Relevant articles and documents

1,3-dibromo-4-fluorobenzene preparation method

The invention discloses an industrial preparation method of 1,3-dibromo-4-fluorobenzene. The industrial preparation method of 1,3-dibromo-4-fluorobenzene comprises the steps that o-fluoronitrobenzeneserves as an initial raw material, and 1,3-dibromo-4-fluorobenzene is synthesized through bromine applying, reduction and diazotization-Sandmeyer three step reactions. The obtained 1,3-dibromo-4-fluorobenzene is yellow oily liquid, the purity is 97.5%, the raw material conversion rates of all steps each reach 100%, and the total recovery of the whole process reaches 52.7%.

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.