1436-27-7

Basic information

• Product Name: 3,6-Diisobutylhexahydropyrazine-2,5-dione
• Synonyms: 3,6-Bis(2-methylpropyl)-2,5-piperazinedione;3,6-Diisobutylhexahydropyrazine-2,5-dione;3,6-Diisobutylpiperazine-2,5-dione;3,6-diisobutyl-2,5-piperazinedione
• CAS NO: 1436-27-7
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.32
• Mol File: 1436-27-7.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 445.2°C at 760 mmHg
• Flash Point: 177.9°C
• Appearance: /
• Density: 0.969g/cm³
• Vapor Pressure: 4.01E-08mmHg at 25°C
• Refractive Index: 1.448
• CAS DataBase Reference: 3,6-Diisobutylhexahydropyrazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-Diisobutylhexahydropyrazine-2,5-dione(1436-27-7)
• EPA Substance Registry System: 3,6-Diisobutylhexahydropyrazine-2,5-dione(1436-27-7)

Safety Data

• Hazardous Substances Data: 1436-27-7(Hazardous Substances Data)

Usage

General Description

3,6-Diisobutylhexahydropyrazine-2,5-dione, also known as quinoxaline-2,3-dione or dibutylphthalide, is a chemical compound with the molecular formula C14H18N2O2. It is a cyclic diketopiperazine that is commonly found in foods and beverages, and is known for its nutty and roasted aroma. It is also used as a flavoring agent in the food industry, particularly in the manufacturing of various types of processed foods and beverages. Additionally, quinoxaline-2,3-dione has been studied for its potential pharmacological properties, including its antiviral, antifungal, and antibacterial activities. However, further research is needed to fully understand its potential applications in the pharmaceutical and food industries.

InChI:InChI=1/C12H22N2O2/c1-7(2)5-9-11(15)14-10(6-8(3)4)12(16)13-9/h7-10H,5-6H2,1-4H3,(H,13,16)(H,14,15)

Upstream product

• 2666-93-5 (S)-Leu-OMe 
• 61-90-5 L-leucine 
• 15136-13-7 N-tert-butoxycarbonyl-L-leucyl-L-leucine methyl ester 
• 1021171-72-1 C₉H₁₇NO₃S 
• 687-51-4 H-L-Leu-NH₂ 
• 2743-60-4 L-Leucine ethyl ester 
• 1738-69-8 L-Leucine benzyl ester 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 60-29-7 diethyl ether 
• 6322-53-8 leucine methyl ester hydrochloride 
• 18869-43-7 DL-leucine methyl ester 
• 56-81-5 glycerol 
• 56-40-6 glycine 
• 328-39-2 LEUCINE 

Downstream Products

• 503-74-2 3-methylbutyric acid 
• 114420-46-1 (2S,5S)-1,4-dibenzyl-2,5-diisobutylpiperazine 
• 2666-93-5 (S)-Leu-OMe 
• 90891-90-0 (R)-α-Benzylleucin-methylester 
• 90891-83-1 (2R,5S)-2-Benzyl-2,5-diisobutyl-3,6-dimethoxy-2,5-dihydro-pyrazine 
• 90891-84-2 (2R,5S)-2-(2-Benzyloxy-ethyl)-2,5-diisobutyl-3,6-dimethoxy-2,5-dihydro-pyrazine 
• 90104-02-2 (S)-(-)-α-Methylleucine methyl ester 
• 90891-81-9 cis-6-Benzyl-3,6-diisopropyl-2,5-dioxohexahydropyrazine 
• 90891-81-9 trans-6-Benzyl-3,6-diisopropyl-2,5-dioxohexahydropyrazine 
• 114362-39-9 (3S,6S)-1,4-dibenzyl-3,6-diisobutyl-piperazine-2,5-dione 

Relevant articles and documents

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Thermally Induced Self-Assembly and Cyclization of l -Leucyl- l -Leucine in Solid State

Thermal treatment of oligopeptides is one of the methods for synthesis of organic nanostructures. However, heating may lead not only to self-assembly of the initial molecules, but also to chemical reactions resulting in the formation of new unexpected nan

Using fast scanning calorimetry to study solid-state cyclization of dipeptide L-leucyl-L-leucine

The possibility of using fast scanning calorimetry (FSC) to study the kinetics of the solid-state cyclization of dipeptide was demonstrated in the present work for the first time. The activation energy and Arrhenius constant of the cyclization of L/

Synthesis of peptides and pyrazines from β-amino alcohols through extrusion of h2 catalyzed by ruthenium pincer complexes: Ligand-controlled selectivity

Your choice: The choice of the Ru-pincer-complex catalyst determines if peptides or pyrazines are formed from β-amino alcohols. Use of PNN complex 1 leads to linear poly(alanine) or to cyclic dipeptides, depending on the R group (see scheme). With the PNP

Interfacial supramolecular biomimetic epoxidation catalysed by cyclic dipeptides

We synthesised a library of cis- and trans-cyclic dipeptides and evaluated their efficacy as catalysts in the asymmetric Weitz-Scheffer epoxidation of trans-chalcone. A thorough investigation relying on structure-activity studies and computational studies provided insights into the mechanism of the process. Our results revealed some structural features required for efficient conversion and for introduction of chirality into the product. The cyclic dipeptide acts as a catalyst by templating a supramolecular arrangement at the aqueous-organic interface required for efficient transformations to occur. Among all cyclic dipeptides investigated, cyclo(Leu-Leu) was the most efficient supramolecular catalyst.