14363-26-9Relevant articles and documents
Paramagnetic NMR of Phenolic Oxime Copper Complexes: A Joint Experimental and Density Functional Study
Bühl, Michael,Ashbrook, Sharon E.,Dawson, Daniel M.,Doyle, Rachel A.,Hrobárik, Peter,Kaupp, Martin,Smellie, Iain A.
, p. 15328 - 15339 (2016)
1H and13C pNMR properties of bis(salicylaldoximato)copper(II) were studied in the solid state using magic-angle-spinning NMR spectroscopy and, for the isolated complex and selected oligomers, using density-functional theory at the PBE0- 1/3//PBE0-D3 level. Large paramagnetic shifts are observed, up to δ(1H)=272 ppm and δ(13C)=1006 ppm (at 298 K), which are rationalised through spin delocalisation from the metal onto the organic ligand and the resulting contact shifts arising from hyperfine coupling. The observed shift ranges are best reproduced computationally using exchange-correlation functionals with a high fraction of exact exchange (such as PBE0- 1/3). Through a combination of experimental techniques and first-principles computation, a near-complete assignment of the observed signals is possible. Intermolecular effects on the pNMR shifts, modelled computationally in the dimers and trimers through effective decoupling between the local spins via A-tensor and total spin rescaling in the pNMR expression, are indicated to be small. Addition of electron-donating substituents and benzannelation of the organic ligand is predicted computationally to induce notable changes in the NMR signal pattern, which suggests that pNMR spectroscopy can be a sensitive probe for the spin distribution in paramagnetic phenolic oxime copper complexes.
Bobtelsky, M.,Jungreis, E.
, p. 449 - 453 (1955)
Copper salisylaldoxime (CuSAL) imparts protective efficacy against visceral leishmaniasis by targeting Leishmania donovani topoisomerase IB
Singh, Manoj Kumar,Bhaumik, Siddhartha Kumar,Karmakar, Subir,Paul, Joydeep,Sawoo, Sudeshna,Majumder, Hemanta K.,Roy, Amit
, p. 8 - 20 (2017)
In?vitro and in?vivo anti-leishmanial efficacy of copper salisylaldoxime (CuSAL), a transition metal complex, was evaluated and the underlying mechanism was studied. In?vitro studies revealed that 30?μM of CuSAL causes 96% reduction in parasite burden in infected macrophages. CuSAL is least toxic in host cells. A dose of 5?mg/kg bodyweight per mice on alternate days (5 doses) gives ～97% protection in both liver and spleen. Moreover, CuSAL potentially inhibits the catalytic activity of LdTOPILS and causes apoptosis of Leishmania parasites through induction of intracellular ROS generation and activation of caspase-like proteases. Interestingly, CuSAL does not inhibit the catalytic activity of human topoisomerase I. The present study illuminated that CuSAL, has potent anti-leishmanial activity, which selectively targets LdTOPILS; and is a safe for human. Therefore, this compound might be highly promising candidate to develop the rational approaches for chemotherapy of human leishmaniasis.
Nanocrystalline mixed ligand complexes of Cu (II), Ni (II), Co(II) with N, O donor ligands: Synthesis, characterization, and antimicrobial activity
Kolhe Nitin,Jadhav Shridhar,Shaikh Sajid,Takate Sushama,Aware Dinkar
, p. 2999 - 3013 (2017/01/09)
In present investigation nanocrystalline mixed ligand complexes were synthesized using 8-hydroxyquinoline, salicylaldoxime with metals like Cu (II), Ni (II) and Co (II). The metal: ligand ratio was found to be 1:1:1. These complexes were characterized usi
