1436413-27-2Relevant articles and documents
Iridium-Catalyzed Transfer Hydrogenation for Construction of Quinolines from 2-Aminobenzyl Alcohols with Enones in Water
Luo, Nanhua,Shui, Hongling,Zhong, Yuhong,Huang, Jiuzhong,Luo, Renshi
, p. 4516 - 4524 (2021/08/20)
Herein, we describe a method for the synthesis of functionalized quinolines from 2-aminobenzyl alcohols with -nsaturatedketones.This method exhibits tolerance to various functional groups and high efficiency, is environmentally benign, and can be performed on a gram scale. Control experiments suggest that this transformation is accomplished by iridium complex catalyzed transfer hydrogenation, which is then followed by Friedl nder cyclization. The results display that alkali is essential for the high selectivities of this catalytic system.
Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines
Chen, Benjamin Wei Jie,Chng, Leng Leng,Yang, Jun,Wei, Yifeng,Yang, Jinhua,Ying, Jackie Y.
, p. 277 - 283 (2013/03/13)
The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with Ag-Pd alloy nanoparticles supported on carbon. Ag-Pd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedlaender synthesis to give polysubstituted quinolines in moderate to good yields.
