14366-59-7

Usage

Uses

Used in Chemical Synthesis:
o-CuMenyl Isopropyl Ether is used as a rearrangement isopropoxybenzene catalyst for the preparation of o-alkylated phenols. This application is crucial in the production of various chemical compounds and intermediates that find use in different industries.
Used in Pharmaceutical Industry:
o-CuMenyl Isopropyl Ether is used in the preparation of potent subtype-selective retinoid x receptor (RXR) agonist. These agonists are important in the development of drugs targeting various medical conditions, particularly those related to the regulation of cellular differentiation and metabolism.

Upstream product

• 187737-37-7 propene 
• 108-95-2 phenol 
• 2741-16-4 isopropoxybenzene 
• 75-30-9 2-iodo-propane 
• 88-69-7 2-(1-methylethyl)phenol 
• 860562-56-7 4-isopropoxy-3-isopropyl-benzoic acid isopropyl ester 
• 7073-94-1 1-bromo-2-isopropylbenzene 
• 75-26-3 isopropyl bromide 
• 161070-01-5 4-isopropoxy-3-isopropyl-benzoic acid 

Downstream Products

• 1632-59-3 3-isopropyl-4-hydroxyacetophenone 
• 1374354-34-3 C₂₈H₄₁NO₂S₂Si 
• 1374354-24-1 C₁₄H₂₁NO₂ 
• 1374354-46-7 C₂₇H₃₄N₂O₃S₂ 
• 1374354-70-7 C₂₆H₃₂N₂O₃S₂ 

Relevant academic research and scientific papers

Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists

We have previously disclosed 1,2,4-oxadiazole derivative 3 as a potent S1P3-sparing S1P1 agonist. Although compound 3 exhibits potent and manageable immunosuppressive efficacy in various in vivo models, recent studies have revealed that its 1,2,4-oxadiazole ring is subjected to enterobacterial decomposition. As provisions for unpredictable issues, a series of alternative compounds were synthesized on the basis of compound 3. Extensive SAR studies led to the finding of 1,3-thiazole 24c with the EC50 value of 3.4 nM for human S1P1, and over 5800-fold selectivity against S1P3. In rat on host versus graft reaction (HvGR), the ID50 value of 24c was determined at 0.07 mg/kg. The pharmacokinetics in rat and monkey is also reported. Compared to compound 3, 24c showed excellent stability against enterobacteria.

The selective reaction of aryl halides with KOH: Synthesis of phenols, aromatic ethers, and benzofurans

The direct and selective synthesis of phenols from aryl/heteroaryl halides and KOH has been achieved through the use of highly active monophosphine-based catalysts derived from Pd2dba3 and ligands L1 or L2 and the biphasic solvent system 1,4-dioxane/H2O. We have also demonstrated a one-pot method of phenol formation/alkylation for the preparation of alkyl aryl ethers from aryl halides. In many instances, this protocol overcomes limitations in existing Pd-catalyzed coupling reactions of aliphatic alcohols with aryl halides. Finally, we demonstrate that substituted benzofurans can be prepared efficiently via a Pd-catalyzed phenol formation/cyclization protocol starting from 2-chloroaryl alkynes. Copyright