14401-91-3

Basic information

• Product Name: 2-methylpyridinium chloride
• Synonyms: 2-methylpyridinium chloride
• CAS NO: 14401-91-3
• Molecular Formula: C₆H₈N*Cl
• Molecular Weight: 129.58742
• EINECS: 238-367-6
• Mol File: 14401-91-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200 °C
• Boiling Point: 127.5°Cat760mmHg
• Flash Point: 26.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 13.5mmHg at 25°C
• CAS DataBase Reference: 2-methylpyridinium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylpyridinium chloride(14401-91-3)
• EPA Substance Registry System: 2-methylpyridinium chloride(14401-91-3)

Safety Data

• Hazardous Substances Data: 14401-91-3(Hazardous Substances Data)

Usage

Purification Methods

A 1:1 mixture of -picoline and HCl is distilled at 275o, then sublimed in a vacuum at 91-91.5o. [Beilstein 20 H 236, 20 III/IV 2685, 20/5 V 474.] B3436

InChI:InChI=1/C6H7N.ClH/c1-6-4-2-3-5-7-6;/h2-5H,1H3;1H

Upstream product

• 109-06-8 α-picoline 
• 6608-47-5 vinylsulfonyl chloride 
• 17881-80-0 (2-picolyl)trimethylsilane 
• 2155-78-4 dichloro(chloromethyl)phosphine 
• 67-52-7 BARBITURIC ACID 
• 88-88-0 2,4,6-trinitrochlorobenzene 
• 98-88-4 benzoyl chloride 

Downstream Products

• 3430-13-5 5-bromo-2-methylpyridine 
• 98-98-6 2-Picolinic acid 
• 109-05-7 2-Methylpiperidin 
• 109-06-8 α-picoline 
• 4385-63-1 2-(4-methoxyphenyl)-6-methyl-pyridine 
• 1929-82-4 nitrapyrin 
• 4377-37-1 2-trichloromethylpyridine 
• 1817-13-6 2-(trichloromethyl)-3,6-dichloropyridine 
• 129-40-8 5-chloro-1-nitroanthraquinone 
• 1197-03-1 2-(trichloromethyl)-5-chloropyridine 
• 1128-16-1 2-(trichloromethyl)-3,5-dichloropyridine 
• 1817-12-5 2-(trichloromethyl)-3-chloropyridine 
• 55934-01-5 2,3,5-trichloropyridine 
• 51492-01-4 2,3-dichloro-6-(trichloromethyl)pyridine 

Relevant articles and documents

Synthesis of 2-Phosphaindolizine and [1,3]Azaphospholo[1,5-a]quinoline

The reaction of (chloromethyl)dichlorophosphine (1) with 2-[(trimethylsilyl)methyl]pyridine (6) and 2-[(trimethylsilyl)methyl]quinoline (12) in THF affords unsubstituted parent 2-phosphaindolizine (5) and [1,3]azaphospholo[1,5-a]quinoline (7). Multinuclear low-temperature NMR spectroscopy was used to investigate the reaction mechanism; a cascade of substitution and cyclization steps involving transient picolylphosphines and phosphorus heterocycles was identified. The molecular and crystal structures of two heterocyclic intermediates and of 7 were determined by single-crystal X-ray diffraction. Moreover, all intermediates and products were characterized by multinuclear 1H, 13C and 31P NMR spectroscopy.

2-methylpyridinium 2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6- tetrahydropyrimidin-4-olate: Synthesis, characterization, single crystal X-ray analysis and evaluation of anticonvulsant/hypnotic activity and toxicity effects

A new type of barbiturate (a pyrimidine derivative) has been prepared through one pot synthesis from the ethanolic solution of 1-chloro-2,4,6- trinitrobenzene, barbituric acid and 2-methylpyridine. The mechanism of the formation of the reported barbiturate involves an intermediate sigma complex formation and proton abstraction reactions. The structure of the title barbiturate has been identified from UV-Vis, FT-IR, 1H NMR, 13C NMR and elemental analysis data. Single crystal XRD studies further confirm the formation of the reported barbiturate. The anticonvulsant activity of the synthesized barbiturate has been tested by Maximal Electro Shock method on albino rats. The title barbiturate showed notable anticonvulsant activity even at low concentration (dose, 25 mg/kg). It also induces hypnosis in albino mice (dose, 100 mg/kg) for a duration of 47 min. Acute toxicity studies on albino mice indicate that LD50 value is >1,500 mg/kg and the animals do not show any behavioral changes. Graphical Abstract: Figure 1 ORTEP view of 2-Methylpyridinium 2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6- tetrahydropyrimidin-4-olate. [Figure not available: see fulltext.]