2155-78-4

Basic information

• Product Name: (chloromethyl)phosphonous dichloride
• Synonyms: Phosphonous dichloride, (chloromethyl)-
• CAS NO: 2155-78-4
• Molecular Formula: CH₂Cl₃P
• Molecular Weight: 151.3593
• Mol File: 2155-78-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 158.2°C at 760 mmHg
• Flash Point: 49.5°C
• Vapor Pressure: 3.44mmHg at 25°C
• CAS DataBase Reference: (chloromethyl)phosphonous dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: (chloromethyl)phosphonous dichloride(2155-78-4)
• EPA Substance Registry System: (chloromethyl)phosphonous dichloride(2155-78-4)

Safety Data

• Hazardous Substances Data: 2155-78-4(Hazardous Substances Data)

Usage

General Description

(chloromethyl)phosphonous dichloride is a chemical compound with the molecular formula CH3Cl2OP. It is a colorless, volatile liquid that is highly reactive and can be toxic if inhaled or absorbed through the skin. (chloromethyl)phosphonous dichloride is primarily used in the production of flame retardants and as a precursor for other organophosphorus compounds. It is also used as a reagent in organic synthesis, particularly in the production of phosphine derivatives and phosphonate esters. Due to its reactivity and potential health hazards, (chloromethyl)phosphonous dichloride must be handled with caution and under strict safety measures in a controlled laboratory environment.

Upstream product

• 186581-53-3 diazomethane 
• 75-09-2 dichloromethane 
• 60-29-7 diethyl ether 
• 7719-12-2 phosphorus trichloride 
• 124862-12-0 P-(chloromethyl)-N,N,N',N'-tetraisopropylphosphonous diamide 
• 3279-26-3 methyl dichlorophosphite 
• 1983-27-3 (chloromethyl)phosphonothioic acid dichloride 

Downstream Products

• 7351-32-8 Chlormethylphosphinsaeure-methylester 
• 154019-19-9 {((CH₃)2CH)2C₆H₃}OPClCH₂Cl 
• 107700-27-6 2-phenyl-3H-1,3,4-diazaphosphole 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 52323-02-1 C-chlorophosphaethyne 
• 196085-28-6 PCl(CH₂Cl)(C₆H₂(C₃H₇)3) 
• 196085-23-1 PCl(CH₂Cl)(C₆H₁₁) 
• 62763-89-7 quinaldine hydrochloride 
• 14401-91-3 picoline hydrochloride 
• 154019-18-8 PCl(CH₂Cl)(N(C₆H₅)2) 
• 111599-25-8 (Amino-phenyl-methyl)-chloromethyl-phosphinic acid 
• 111599-26-9 (1-Amino-2-phenyl-ethyl)-chloromethyl-phosphinic acid 
• 35449-83-3 Chloromethyl-(hydroxy-phenyl-methyl)-phosphinic acid 

Relevant articles and documents

A “masked” source for the phosphaalkene MesP=CH2: Trapping, rearrangement, and oligomerization

We report the attempted synthesis of a “masked” phosphaalkene by treating MgA·3THF (A?=?anthracenide) with MesPCl(CH2Cl). Although the desired “masked” phosphaalkene could not be isolated, indirect evidence for its formation was obtained. The product of trapping MesP=CH2 with 1,3-cyclohexadiene was detected. In addition, the oxide MesPO(Me)A was isolated and crystallographically characterized from the MgA·3THF and MesPCl(CH2Cl) experiment described above. Finally, the attempted isolation of “masked” phoshaalkene afforded P-containing oligomers with a trimodal molecular weight distribution [Mn?=?640, 1.7?×?103 and 7.4?×?103?Da].

1,4,2-Diazaphospholothiazoles and -pyridines by a Hantzsch-Type Condensation Using Chloromethyldichlorophosphane

The cyclocondensation of 2-amino-1,3-thiazoline, 2-aminopyridines, 2- and 4-aminopyrimidines, 2-aminopyrazine, and 2-aminoquinoline with chloromethyldichlorophosphane in the presence of triethylamine yields regiospecifically 5,6-dihydrothiazolodiazaphosphole (3), 1,4,2-diazaphospholopyridines (12), 1,4,2-diazaphospholopyrimidines (15), 1,4,2-diazaphospholopyrimidine (17), 1,4,2-diazaphospholopyrazine (19), and diazaphospholoquinoline (22), respectively.Using 2-amino-1,3-thiazole (4) and 2-aminobenzothiazoles 8, we obtained mixtures of the 1,5- and 4,5-anellated 1,4,2-diazaphospholes 5/6, 9a/10a and 9b/10b, while in the case of the methyl derivative 8c only the diazaphospholobenzothiazole 10c was formed.In the reaction of 2-aminothiazole and 2-aminopyrazine with chloromethyldichlorophosphane the bis(diazaphospholo)-substituted chloromethylphosphanes 7 and 20 could be detected.The new anellated 1,4,2-diazaphospholes are colorless to pale yellow crystalline moisture-sensitive solids. - Key Words: Anellated azaphospholes/ Hantzsch-type cyclocondensation/ Chloromethyldichlorophosphane/ Regioselectivity/ 31P-, 1H-, 13-C-NMR spectra

CHLOROTROPY IN THE P-C DYAD. II. CHLOROTROPIC CONVERSIONS OF BIS(DIISOPROPYLAMIDES) OF α-CHLOROALKYLPHOSPHONOUS ACIDS

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